Giardia duodenalis: biology and pathogenesis

RD Adam - Clinical microbiology reviews, 2021 - Am Soc Microbiol
Giardia duodenalis captured the attention of Leeuwenhoek in 1681 while he was examining
his own diarrheal stool, but, ironically, it did not really gain attention as a human pathogen …

Foraminifera as a model of the extensive variability in genome dynamics among eukaryotes

EJ Goetz, M Greco, HB Rappaport, AKM Weiner… - …, 2022 - Wiley Online Library
Abstract Knowledge of eukaryotic life cycles and associated genome dynamics stems
largely from research on animals, plants, and a small number of “model”(ie, easily cultivable) …

[HTML][HTML] An update on cell division of Giardia duodenalis trophozoites

FA Lagunas-Rangel, J Yee… - Microbiological Research, 2021 - Elsevier
Giardia duodenalis is a flagellated protozoan that is responsible for many cases of diarrheal
disease worldwide and is characterized by its great divergence from the model organisms …

Highly contiguous genomes of human clinical isolates of Giardia duodenalis reveal assemblage- and sub-assemblage-specific presence–absence variation in …

C Klotz, MW Schmid, K Winter, R Ignatius… - Microbial …, 2023 - microbiologyresearch.org
Giardia duodenalis (syn. G. intestinalis, G. lamblia) is a widespread gastrointestinal
protozoan parasite with debated taxonomic status. Currently, eight distinct genetic sub …

Efficient CRISPR/Cas9-mediated gene disruption in the tetraploid protist Giardia intestinalis

V Horáčková, L Voleman, KD Hagen… - Open …, 2022 - royalsocietypublishing.org
CRISPR/Cas9-mediated genome editing has become an extremely powerful technique
used to modify gene expression in many organisms, including parasitic protists. Giardia …

Clues on the dynamics of DNA replication in Giardia lamblia

MS da Silva, MO Vitarelli, VL Viala… - Journal of cell …, 2023 - journals.biologists.com
Genomic replication is a critical, regulated process that ensures accurate genetic information
duplication. In eukaryotic cells, strategies have evolved to prevent conflicts between …

Comprehensive analysis of flavohemoprotein copy number variation in Giardia intestinalis: exploring links to metronidazole resistance

V Korenková, F Weisz, A Perglerová, SM Cacciò… - Parasites & …, 2024 - Springer
Background Giardiasis, caused by the protozoan parasite Giardia intestinalis, often presents
a treatment challenge, particularly in terms of resistance to metronidazole. Despite extensive …

Implementation of a tunable t-CRISPRi system for gene regulation in Giardia duodenalis

E García-Huerta, S Espinoza-Corona… - Plasmid, 2022 - Elsevier
Giardia duodenalis, is a binuclear and microaerophilic protozoan that causes giardiasis. Up
to date, several molecular approaches have been taken to understand the molecular …

Giardiasis from a One Health Perspective

M Lalle, SM Cacciò - Zoonoses: Infections Affecting Humans and Animals, 2023 - Springer
The flagellated protozoan Giardia duodenalis is the etiologic agent of giardiasis, a very
common gastrointestinal infection of mammals, including humans, with a global distribution …

Regulation of differentiation during the Giardia life cycle: An insight into the molecular control

L Rojas-López - 2022 - diva-portal.org
Rojas-López, L. 2022. Regulation of differentiation during the Giardia life cycle. An insight
into the molecular control. Digital Comprehensive Summaries of Uppsala Dissertations from …