Abstract Iron-sulfur (Fe/S) proteins are present in virtually all living organisms and are
involved in numerous cellular processes such as respiration, photosynthesis, metabolic …

Iron is a crucial transition metal for virtually all life. Two major destinations of iron within
mammalian cells are the cytosolic iron-storage protein, ferritin, and mitochondria. In …

Iron is an essential but potentially hazardous biometal. Mammalian cells require sufficient
amounts of iron to satisfy metabolic needs or to accomplish specialized functions. Iron is …

Abstract Iron–sulphur (Fe–S) clusters have long been recognized as essential and versatile
cofactors of proteins involved in catalysis, electron transport and sensing of ambient …

Cellular iron homeostasis is maintained by iron regulatory proteins 1 and 2 (IRP1 and IRP2).
IRPs bind to iron-responsive elements (IREs) located in the untranslated regions of mRNAs …

Hydroxyurea is a well-established inhibitor of ribonucleotide reductase that has a long
history of scientific interest and clinical use for the treatment of neoplastic and non …

Mitochondria play a key role in iron metabolism in that they synthesize heme, assemble iron–
sulfur (Fe/S) proteins, and participate in cellular iron regulation. Here, we review the latter …

Eukaryotic cells contain numerous iron-requiring proteins such as iron-sulfur (Fe-S) cluster
proteins, hemoproteins and ribonucleotide reductases (RNRs). These proteins utilize iron as …

The eukaryotic replicative DNA polymerases (Pol α, δ and ɛ) and the major DNA
mutagenesis enzyme Pol ζ contain two conserved cysteine-rich metal-binding motifs (CysA …

Iron–sulfur (Fe/S) clusters (ISCs) are redox-active protein cofactors that their synthesis,
transfer, and insertion into target proteins require many components. Mitochondrial ISC …