Critical examination of mechanisms underlying the reduction in heart failure events with SGLT2 inhibitors: identification of a molecular link between their actions to …
M Packer - Cardiovascular research, 2021 - academic.oup.com
Abstract Sodium-glucose co-transporter 2 (SGLT2) inhibitors reduce the risk of serious heart
failure events, even though SGLT2 is not expressed in the myocardium. This …
failure events, even though SGLT2 is not expressed in the myocardium. This …
Targeting autophagy drug discovery: Targets, indications and development trends
M Jiang, W Wu, Z Xiong, X Yu, Z Ye, Z Wu - European Journal of Medicinal …, 2024 - Elsevier
Autophagy plays a vital role in sustaining cellular homeostasis and its alterations have been
implicated in the etiology of many diseases. Drugs development targeting autophagy began …
implicated in the etiology of many diseases. Drugs development targeting autophagy began …
Exercise training modifies the whole blood DNA methylation profile in middle-aged and older women
G da Silva Rodrigues, NY Noronha… - Journal of Applied …, 2023 - journals.physiology.org
This is a longitudinal single-arm clinical trial aimed to investigate whether exercise training
would modify the whole blood methylation profile in healthy women. A total of 45 subjects …
would modify the whole blood methylation profile in healthy women. A total of 45 subjects …
[HTML][HTML] What should be responsible for eryptosis in chronic kidney disease?
D Li, X Zheng, Y Zhang, X Li, X Chen, Y Yin… - Kidney and Blood …, 2022 - karger.com
Background: Renal anemia is an important complication of chronic kidney disease (CKD). In
addition to insufficient secretion of erythropoietin (EPO) and erythropoiesis disorders, the …
addition to insufficient secretion of erythropoietin (EPO) and erythropoiesis disorders, the …
Targeting autophagy with small-molecule activators for potential therapeutic purposes
Z Fan, LX Wan, W Jiang, B Liu, D Wu - European Journal of Medicinal …, 2023 - Elsevier
Autophagy is well-known to be a lysosome-mediated catabolic process for maintaining
cellular and organismal homeostasis, which has been established with many links to a …
cellular and organismal homeostasis, which has been established with many links to a …
Research progress of AMP-activated protein kinase and cardiac aging
Z Qiu, Y Li, Y Fu, Y Yang - Open Life Sciences, 2023 - degruyter.com
The process of aging is marked by a gradual deterioration in the physiological functions and
functional reserves of various tissues and organs, leading to an increased susceptibility to …
functional reserves of various tissues and organs, leading to an increased susceptibility to …
GSK621 ameliorates high glucose-induced renal injury by inducing autophagy via AMPK/ULK1 signaling pathway: an in vitro and in vivo study
H Dong, Y Yang - Molecular & Cellular Toxicology, 2024 - Springer
Background Diabetic nephropathy (DN) could lead to renal failure and its morbidity is
increasing throughout the world. The activation of AMP-activated protein kinase (AMPK) has …
increasing throughout the world. The activation of AMP-activated protein kinase (AMPK) has …
Band 3 ectopic expression in colorectal cancer induces an increase in erythrocyte membrane-bound IgG and may cause immune-related anemia
A Kitao, S Kawamoto, K Kurata, I Hayakawa… - International Journal of …, 2020 - Springer
Autoimmune hemolytic anemia (AIHA) is a rare comorbidity in colorectal cancer (CRC) and
has an unknown etiology. Previously, we described an AIHA case secondary to CRC with …
has an unknown etiology. Previously, we described an AIHA case secondary to CRC with …
Liver kinase B1 (LKB1) in murine erythroid progenitors modulates erythropoietin setpoint in association with maturation control
Z White III, KE Elagib, AA Gru, AN Goldfarb - Blood Cells, Molecules, and …, 2022 - Elsevier
Erythropoiesis is a tightly regulated process. It is stimulated by decreased oxygen in
circulation, which leads to the secretion of the hormone erythropoietin (Epo) by the kidneys …
circulation, which leads to the secretion of the hormone erythropoietin (Epo) by the kidneys …
[PDF][PDF] What should be responsible for eryptosis in chronic kidney
D Li, X Zheng, Y Zhang, X Li, X Chen, Y Yin, J Hu, J Li… - 2022 - scholar.archive.org
Background: Renal anemia is an important complication of chronic kidney disease (CKD). In
addition to insufficient secretion of erythropoietin (EPO) and erythropoiesis disorders, the …
addition to insufficient secretion of erythropoietin (EPO) and erythropoiesis disorders, the …