Epithelial cells are the most common cell type in all animals, forming the sheets and tubes
that compose most organs and tissues. Apical–basal polarity is essential for epithelial cell …

The eukaryotic cell is compartmentalized into subcellular niches, including membrane-
bound and membrane-less organelles. Proteins localize to these niches to fulfil their …

The textbook view of cell division terminates with the final separation of the two daughter
cells in the process called abscission. However, in contrast to this classical view, a variety of …

During development, the conserved PAR polarity network is continuously redeployed,
requiring that it adapt to changing cellular contexts and environmental cues. In the early C …

The difficulty of retrieving high-resolution, in vivo evidence of the proliferative and migratory
processes occurring in neural germinal zones has limited our understanding of …

During organismal development, organs and systems are built following a genetic blueprint
that produces structures capable of performing specific physiological functions. Interestingly …

Vital internal organs display a left-right (LR) asymmetric arrangement that is established
during embryonic development. Disruption of this LR asymmetry—or laterality—can result in …

The centrosome is a highly conserved structure composed of two centrioles surrounded by
pericentriolar material. The mother, and inherently older, centriole has distal and subdistal …

Tissue-wide patterning is essential to multicellular development, requiring cells to
individually generate polarity axes and coordinate them in space and time with neighbors …

To complete cytokinesis, abscission of the proteinaceous and microtubule-rich intercellular
bridge needs to occur. The midbody (MB), a structure that forms on the intercellular bridge, is …