Inflammation is a complicated biological and pathophysiological cascade of responses to
infections and injuries, and inflammatory mechanisms are closely related to many diseases …

Immune dysregulation, polyendocrinopathy, enteropathy, X‐linked (IPEX) syndrome is a
rare disorder that increasingly has gained attention as a model of genetic autoimmunity …

Immune tolerance is maintained in lymphoid organs (LOs). Despite the presence of complex
immune cell networks in non-LOs, it is unknown whether self-tolerance is maintained in …

Inhibitory signals through the PD-1 pathway regulate T cell activation, T cell tolerance, and T
cell exhaustion. Studies of PD-1 function have focused primarily on effector T cells. Far less …

The inflammasome initiates innate defence and inflammatory responses by activating
caspase-1 and pyroptotic cell death in myeloid cells,. It consists of an innate immune …

Regulatory T (Treg) cells are required to control immune responses and maintain
homeostasis, but are a significant barrier to antitumour immunity. Conversely, Treg …

Summary Foxp3+ T regulatory (Treg) cells prevent inflammatory disease but the mechanistic
basis of suppression is not understood completely. Gene silencing by RNA interference can …

Regulatory T cells (Tregs) are critical for maintaining immune homeostasis, but their
presence in tumor tissues impairs anti-tumor immunity and portends poor prognoses in …

Foxp3-expressing regulatory T cells (Tregs) reside in tissues where they control
inflammation and mediate tissue-specific functions. The skin of mice and humans contain a …

The mechanisms by which regulatory T (Treg) cells differentially control allergic and
autoimmune responses remain unclear. We show that Treg cells in food allergy (FA) had …