L-lysine α-oxidase (LO), one of L-amino acid oxidases, deaminates L-lysine with the yield of
H2O2, ammonia, and α-keto-ε-aminocaproate. Multiple in vitro and in vivo studies have …

Cancer is usually a result of abnormal glucose uptake and imbalanced nutrient
metabolization. The dysregulation of glucose metabolism, which controls the processes of …

Background Cisplatin (DDP)-based chemotherapy is commonly adopted as the first-line
treatment for patients with oesophageal squamous cell carcinoma (OSCC), but the high rate …

Downregulation of the urea cycle enzyme argininosuccinate synthase (ASS1) in multiple
tumors is associated with a poor prognosis partly because of the metabolic diversion of …

Purpose l-arginine (L-arg) deficiency causes immunosuppression, but it is unknown if L-arg
supplementation in colorectal cancer (CRC) patients restores immune system activity. Our …

Cancer may be considered one of the most interesting areas of study, and although
oncology research has grown markedly over the last decade, there is as yet no known cure …

Cellular metabolic reprogramming driven by oncogenic mutations is considered as a
hallmark in the development of malignant cells, and has been a focus over the past decade …

Arginase-1 ist ein zytosolisches Enzym, das die Umwandlung von Arginin in Ornithin und
Harnstoff im letzten Schritt des Harnstoffzyklus katalysiert. Aufgrund seiner überwiegenden …

Cancer cells develop under nutrient and oxygen deficient microenvironment caused by
insufficient vascularization. Reprogramming metabolism meets the needs of the rapid …