Importance Mediation analyses of randomized trials and observational studies can generate
evidence about the mechanisms by which interventions and exposures may influence health …

Evidence from human cohorts indicates that chronic insomnia is associated with higher risk
of cardiometabolic diseases (CMD), yet whether gut microbiota plays a role is unclear. Here …

Emerging research suggests that exposures occurring years before conception are
important determinants of the health of future offspring and subsequent generations …

Objective: We provide an overview of regression-based causal mediation analysis in the
field of traumatic stress and guidance on how to conduct mediation analysis using our R …

Effective infectious disease surveillance in high-risk regions is critical for clinical care and
pandemic preemption; however, few clinical diagnostics are available for the wide range of …

Mediation analysis is a method that quantifies how health exposures, such as medical
interventions, change patient outcomes. Evidence that is generated from mediation analyses …

When epidemiologic studies are conducted in a subset of the population, selection bias can
threaten the validity of causal inference. This bias can occur whether or not that selected …

Background Although ample evidence has shown the link between childhood obesity and
socioeconomic status including family income and household education levels, the …

An improved understanding of the biopsychosocial influences that contribute to and
maintain pain has promoted the development of new efficacious treatments for chronic low …

Mechanistic research suggests that lifestyle and environmental factors impact respiratory
health across generations by epigenetic changes transmitted through male germ cells …