Background. Extracellular vesicles (EVs) play an essential role in the communication
between cells and transport of diagnostically significant molecules. A wide diversity of …

Uromodulin (also known as Tamm-Horsfall protein) is exclusively produced in the kidney
and is the most abundant protein in normal urine. The function of uromodulin remains …

Hypertension and chronic kidney disease (CKD) are complex traits representing major
global health problems 1, 2. Multiple genome-wide association studies have identified …

Uromodulin, a protein exclusively produced by the kidney, is the most abundant urinary
protein in physiological conditions. Already described several decades ago, uromodulin has …

Uromodulin is the most abundant protein in human urine, and it forms filaments that
antagonize the adhesion of uropathogens; however, the filament structure and mechanism …

Autosomal dominant tubulointerstitial kidney disease (ADTKD) is an increasingly recognized
cause of end-stage kidney disease, primarily due to mutations in UMOD and MUC1. The …

Background An ELISA to analyse uromodulin in human serum (sUmod) was developed,
validated and tested for clinical applications. Methods We assessed sUmod, a very stable …

Biology has taught us that a protein as abundantly made and conserved among species as
Tamm–Horsfall protein (THP or uromodulin) cannot just be a waste product serving no …

Results In both studies, positive associations were found between uromodulin and urinary
sodium, chloride, and potassium excretion and osmolality. In SKIPOGH, 24-hour uromodulin …

The mucoprotein uromodulin is the most abundant protein in mammalian urine and has
important roles in ion transport, maintenance of water and electrolyte balance, and …