Access to Axially Chiral Biaryl Benzylamines via Ancestral Enzyme-Enabled Reductive Amination Desymmetrization
WQ Zheng, XX Zhu, Z Zhu, T Yang, L Zheng… - ACS …, 2025 - ACS Publications
Axially chiral biaryl benzylamines are present in numerous natural products,
pharmaceuticals, chiral ligands, and catalysts. However, the direct catalytic synthesis of …
pharmaceuticals, chiral ligands, and catalysts. However, the direct catalytic synthesis of …
Dynamic Kinetic Reductive Grignard-Type Addition for the Construction of Axial and Central Chirality
YP Shao, YM Liang - ACS Catalysis, 2025 - ACS Publications
This study describes a photoredox/cobalt dual-catalyzed asymmetric Grignard-type addition
reaction, enabling the synthesis of axially chiral hexatomic (six–six) N-heterobiaryls bearing …
reaction, enabling the synthesis of axially chiral hexatomic (six–six) N-heterobiaryls bearing …
Engineered Imine Reductase Catalyzed Enantiodivergent Synthesis of Alkylated Amphetamines
Less steric ketones exhibited low stereoselectivity toward M5 due to their difficulty in
restricting the free rotation of the imine intermediate. An engineered enantio-complementary …
restricting the free rotation of the imine intermediate. An engineered enantio-complementary …
Synthetic Nicotinamide Cofactors as Alternatives to NADPH in Imine Reductase-Catalyzed Reactions
W Kang, S Gao, J Bao, L Yang, Y Ma, P Wang… - Organic …, 2024 - ACS Publications
This study demonstrates the effectiveness of synthetic nicotinamide cofactors as cost-
effective alternatives to NADPH in imine reductase (IRED) catalysis. The synthetic cofactors …
effective alternatives to NADPH in imine reductase (IRED) catalysis. The synthetic cofactors …