CD36, also known as the scavenger receptor B2, is a multifunctional receptor widely
expressed in various organs. CD36 plays a crucial role in the uptake of long-chain fatty …

CD36 is highly expressed in diverse tumor types and its expression correlates with
advanced stages, poor prognosis, and reduced survival. In cancer cells, CD36: 1) increases …

Vascular diseases account for a significant number of deaths worldwide, with cardiovascular
diseases remaining the leading cause of mortality. This ongoing, ever-increasing burden …

Diabetic macroangiopathy is a leading cause of diabetes-related mortality worldwide. Both
genetic and environmental factors, through a multitude of underlying molecular …

Tumor-associated macrophages (TAMs) constitute an important part of the tumor
microenvironment (TME) that regulates tumor progression. Tumor-derived signals, hypoxia …

Adrenomedullin (ADM) 2/intermedin (IMD) is a short peptide that belongs to the CGRP
superfamily. Although it shares receptors with CGRP, ADM and amylin, ADM2 has …

Metformin has been suggested to have cardiovascular protective effects. Previous
researches showed that metformin activates Adenosine Monophosphate Activated Protein …

Adrenomedullin 2 (ADM2) is an endogenous bioactive peptide belonging to the calcitonin
gene-related peptide family. Our previous studies showed that overexpression of ADM2 in …

T cell metabolic activation plays a crucial role in inflammation of atherosclerosis. Shikonin
(SKN), a natural naphthoquinone with anti-inflammatory activity, has shown to exert …

oxLDL is involved in the pathogenesis of atherosclerotic lesions through cholesterol
accumulation in macrophage foam cells. Andrographolide, the bioactive component of …