To flourish, cancers greatly depend on their surrounding tumor microenvironment (TME),
and cancer-associated fibroblasts (CAFs) in TME are critical for cancer occurrence and …

Mutation-induced activation of WNT–β-catenin signalling is a frequent driver event in human
cancer. Sustained WNT–β-catenin pathway activation endows cancer cells with sustained …

The ubiquitin–proteasome system (UPS) plays an important role in the cellular processes for
protein quality control and homeostasis. Dysregulation of the UPS has been implicated in …

In vitro cell cultures are crucial research tools for modeling human development and
diseases. Although the conventional monolayer cell cultures have been widely used in the …

Many tumour cells show dependence on exogenous serine and dietary serine and glycine
starvation can inhibit the growth of these cancers and extend survival in mice. However …

Hepatocellular carcinoma (HCC), the major form of liver cancer, has shown increasing
incidence and poor prognosis. Adipose tissue is known to function in energy storage and …

Abstract β‑catenin/CTNNB1 is an intracellular scaffold protein that interacts with adhesion
molecules (E‑cadherin/CDH1, N‑cadherin/CDH2, VE‑cadherin/CDH5 and α‑catenins) …

Colorectal cancer (CRC) is one of the most common forms of solid tumors in the world with
high rates of mortality and morbidity. Most cases of CRCs are initiated by inactivating …

The assembly and activation of the inflammasomes are tightly regulated by post‐
translational modifications, including ubiquitin. Deubiquitinases (DUBs) counteract the …

The Wnt signaling pathway plays important roles in embryonic development, homeostatic
processes, cell differentiation, cell polarity, cell proliferation, and cell migration via the β …