Signaling pathways in cancer-associated fibroblasts and targeted therapy for cancer
F Wu, J Yang, J Liu, Y Wang, J Mu, Q Zeng… - … and Targeted Therapy, 2021 - nature.com
To flourish, cancers greatly depend on their surrounding tumor microenvironment (TME),
and cancer-associated fibroblasts (CAFs) in TME are critical for cancer occurrence and …
and cancer-associated fibroblasts (CAFs) in TME are critical for cancer occurrence and …
Mutations and mechanisms of WNT pathway tumour suppressors in cancer
Mutation-induced activation of WNT–β-catenin signalling is a frequent driver event in human
cancer. Sustained WNT–β-catenin pathway activation endows cancer cells with sustained …
cancer. Sustained WNT–β-catenin pathway activation endows cancer cells with sustained …
Ubiquitin–proteasome system (UPS) as a target for anticancer treatment
J Park, J Cho, EJ Song - Archives of pharmacal research, 2020 - Springer
The ubiquitin–proteasome system (UPS) plays an important role in the cellular processes for
protein quality control and homeostasis. Dysregulation of the UPS has been implicated in …
protein quality control and homeostasis. Dysregulation of the UPS has been implicated in …
A brief history of organoids
C Corrò, L Novellasdemunt… - American Journal of …, 2020 - journals.physiology.org
In vitro cell cultures are crucial research tools for modeling human development and
diseases. Although the conventional monolayer cell cultures have been widely used in the …
diseases. Although the conventional monolayer cell cultures have been widely used in the …
Serine synthesis pathway inhibition cooperates with dietary serine and glycine limitation for cancer therapy
M Tajan, M Hennequart, EC Cheung, F Zani… - Nature …, 2021 - nature.com
Many tumour cells show dependence on exogenous serine and dietary serine and glycine
starvation can inhibit the growth of these cancers and extend survival in mice. However …
starvation can inhibit the growth of these cancers and extend survival in mice. However …
RETRACTED ARTICLE: exosome circRNA secreted from adipocytes promotes the growth of hepatocellular carcinoma by targeting deubiquitination-related USP7
H Zhang, T Deng, S Ge, Y Liu, M Bai, K Zhu, Q Fan, J Li… - Oncogene, 2019 - nature.com
Hepatocellular carcinoma (HCC), the major form of liver cancer, has shown increasing
incidence and poor prognosis. Adipose tissue is known to function in energy storage and …
incidence and poor prognosis. Adipose tissue is known to function in energy storage and …
[HTML][HTML] Multi‑layered prevention and treatment of chronic inflammation, organ fibrosis and cancer associated with canonical WNT/β‑catenin signaling activation
M Katoh - International journal of molecular …, 2018 - build.spandidos-publications.com
Abstract β‑catenin/CTNNB1 is an intracellular scaffold protein that interacts with adhesion
molecules (E‑cadherin/CDH1, N‑cadherin/CDH2, VE‑cadherin/CDH5 and α‑catenins) …
molecules (E‑cadherin/CDH1, N‑cadherin/CDH2, VE‑cadherin/CDH5 and α‑catenins) …
Role of adenomatous polyposis coli (APC) gene mutations in the pathogenesis of colorectal cancer; current status and perspectives
Colorectal cancer (CRC) is one of the most common forms of solid tumors in the world with
high rates of mortality and morbidity. Most cases of CRCs are initiated by inactivating …
high rates of mortality and morbidity. Most cases of CRCs are initiated by inactivating …
USP7 and USP47 deubiquitinases regulate NLRP3 inflammasome activation
The assembly and activation of the inflammasomes are tightly regulated by post‐
translational modifications, including ubiquitin. Deubiquitinases (DUBs) counteract the …
translational modifications, including ubiquitin. Deubiquitinases (DUBs) counteract the …
Regulation of Wnt signaling through ubiquitination and deubiquitination in cancers
HB Park, JW Kim, KH Baek - International Journal of Molecular Sciences, 2020 - mdpi.com
The Wnt signaling pathway plays important roles in embryonic development, homeostatic
processes, cell differentiation, cell polarity, cell proliferation, and cell migration via the β …
processes, cell differentiation, cell polarity, cell proliferation, and cell migration via the β …