Background: Antibiotic-resistant bacteria pose a global health threat. Traditional antibiotics
can lose their effectiveness, and the development of novel effective antimicrobials has …

Alkaloids are nitrogen-containing heterocyclic compounds typically isolated from plants.
They represent one of the most important types of natural products because of their large …

Quorum sensing is a cell-to-cell communication system that exists widely in the microbiome
and is related to cell density. The high-density colony population can generate a sufficient …

Multidrug efflux pumps function at the frontline to protect bacteria against antimicrobials by
decreasing the intracellular concentration of drugs. This protective barrier consists of a …

The increasing emergence of antimicrobial resistance in staphylococcal bacteria is a major
health threat worldwide due to significant morbidity and mortality resulting from their …

Abuse of antibiotics has led to the emergence of drug-resistant pathogens. Methicillin-
resistant Staphylococcus aureus (MRSA) was reported just two years after the clinical use of …

Background The discovery and use of antibiotics have produced tremendous benefits for
human society, however, with the large-scale use of antibiotics in medicine, animal …

Background The evolution of resistance to antimicrobials is a ubiquitous phenomenon. The
evolution of antibiotic resistance in Staphylococcus aureus suggests that there is no remedy …

The emergence of pathogenic and drug-resistant microorganisms seriously threatens public
safety. This work constructed a unique type of thiazolyl hydrazineylidenyl indolones (THIs) to …

Infection is a huge obstacle to wound healing. Thus, to enhance the healing of infected
wounds, wound dressings that permit the dual delivery of antimicrobials and antioxidants …