Thoracic aortopathy, especially aneurysm, dissection, and rupture, is responsible for
significant morbidity and mortality. Uncontrolled hypertension and aging are primary risk …

Hypertension induces significant aortic remodelling, often adaptive but sometimes not. To
identify immuno-mechanical mechanisms responsible for differential remodelling, we …

Thoracic aortic aneurysms are life-threatening lesions that afflict young and old individuals
alike. They frequently associate with genetic mutations and are characterized by reduced …

Considerable insight into effectors of cardiovascular function can be gleaned from controlled
studies on mice, especially given the diverse models that are available. Toward this end …

Findings from basic science and clinical studies agree that arterial stiffness is fundamental to
both the mechanobiology and the biomechanics that dictate vascular health and disease …

Mouse models provide unique opportunities to study vascular disease, but they demand
increased experimental and computational resolution. We describe a workflow for …

Fibrillin-1 is an elastin-associated glycoprotein that contributes to the long-term fatigue
resistance of elastic fibers as well as to the bioavailability of transforming growth factor-beta …

Elastin and collagen fibers are the major load-bearing extracellular matrix (ECM)
constituents of the vascular wall. Arteries function differently than veins in the circulatory …

Background Using animal models in experimental medicine requires mapping of their
anatomical variability. Porcine common carotid arteries (CCA) are often preferred for the …

Maternal mortality due to cardiovascular disease is a rising concern in the US Pregnancy
triggers changes in the circulatory system, potentially influencing the structure of the central …