Natural killer (NK) cells form a subset of lymphocytes that play a key role in immuno-
surveillance and host defense against cancer and viral infections. They recognize stressed …

Natural killer (NK) cells are major contributors to immunosurveillance and control of tumor
development by inducing apoptosis of malignant cells. Among the main mechanisms …

Cytotoxic lymphocytes serve a key role in immune homeostasis by eliminating virus-infected
and transformed target cells through the perforin-dependent delivery of proapoptotic …

Pneumolysin is a member of the cholesterol-dependent cytolysin (CDC) family of pore-
forming proteins that are produced as water-soluble monomers or dimers, bind to target …

The mushroom Pleurotus ostreatus has been reported to produce the hemolytic proteins
ostreolysin (OlyA), pleurotolysin A (PlyA) and pleurotolysin B (PlyB). The present study of the …

Experimental and theoretical studies on ion–lipid interactions predict that binding of calcium
ions to cell membranes leads to macroscopic mechanical effects and membrane …

Perforin-mediated cytotoxicity is an essential host defense, in which defects contribute to
tumor development and pathogenic disorders including autoimmunity and autoinflammation …

Considerable progress has been made in understanding how cytotoxic lymphocytes use the
highly toxic pore-forming protein perforin to eliminate dangerous cells, while remaining …

Pore-forming proteins (PFPs) are a heterogeneous group of proteins that are expressed and
secreted by a wide range of organisms. PFPs are produced as soluble monomers that bind …

Recent work on the MACPF/CDC superfamily of pore-forming proteins has focused on the
structural analysis of monomers and pore-forming oligomeric complexes. We set the family …