Tumors are comprised of both cancer cells and surrounding stromal components. As an
essential part of the tumor microenvironment, the tumor stroma is highly dynamic …

Mutationally corrupted cancer (stem) cells are the driving force of tumor development and
progression. Yet, these transformed cells cannot do it alone. Assemblages of ostensibly …

Mass-spectrometry-based proteomic profiling of human cancers has the potential for pan-
cancer analyses to identify molecular subtypes and associated pathway features that might …

As angiogenesis is essential for tumor growth and metastasis, controlling tumor-associated
angiogenesis is a promising tactic in limiting cancer progression. The tumor …

The hallmarks of cancer described by Hanahan and Weinberg have proved seminal in our
understanding of cancer's common traits and in rational drug design. Not free of critique and …

Recently, phage display technology has been announced as the recipient of Nobel Prize in
Chemistry 2018. Phage display technique allows high affinity target-binding peptides to be …

Metabolic interaction between cancer-associated fibroblasts (CAFs) and colorectal cancer
(CRC) cells plays a major role in CRC progression. However, little is known about lipid …

Maintenance of both normal epithelial tissues and their malignant counterparts is supported
by the host tissue stroma. The tumor stroma mainly consists of the basement membrane …

Stromal cells in the tumor microenvironment (TME) closely interact with tumor cells and
affect tumor cell behavior in diverse manners. We herein investigated the mechanisms by …

Cancer associated fibroblasts (CAFs) are a subpopulation of cells that reside within the
tumor microenvironment and promotes the transformation process by encouraging tumor …