Mechanisms of deep brain stimulation

TM Herrington, JJ Cheng… - Journal of …, 2016 - journals.physiology.org
Deep brain stimulation (DBS) is widely used for the treatment of movement disorders
including Parkinson's disease, essential tremor, and dystonia and, to a lesser extent, certain …

Cellular, molecular, and clinical mechanisms of action of deep brain stimulation—a systematic review on established indications and outlook on future developments

M Jakobs, A Fomenko, AM Lozano… - EMBO molecular …, 2019 - embopress.org
Deep brain stimulation (DBS) has been successfully used to treat movement disorders, such
as Parkinson's disease, for more than 25 years and heralded the advent of electrical …

History, applications, and mechanisms of deep brain stimulation

S Miocinovic, S Somayajula, S Chitnis… - JAMA neurology, 2013 - jamanetwork.com
Deep brain stimulation (DBS) is an effective surgical treatment for medication-refractory
hypokinetic and hyperkinetic movement disorders, and it is being explored for a variety of …

Pathological synchronization in Parkinson's disease: networks, models and treatments

C Hammond, H Bergman, P Brown - Trends in neurosciences, 2007 - cell.com
Parkinson's disease is a common and disabling disorder of movement owing to
dopaminergic denervation of the striatum. However, it is still unclear how this denervation …

Normal and pathological oscillatory communication in the brain

A Schnitzler, J Gross - Nature reviews neuroscience, 2005 - nature.com
The huge number of neurons in the human brain are connected to form functionally
specialized assemblies. The brain's amazing processing capabilities rest on local …

Deep brain stimulation

JS Perlmutter, JW Mink - Annu. Rev. Neurosci., 2006 - annualreviews.org
Deep brain stimulation (DBS) has provided remarkable benefits for people with a variety of
neurologic conditions. Stimulation of the ventral intermediate nucleus of the thalamus can …

High-frequency stimulation of the subthalamic nucleus suppresses oscillatory β activity in patients with Parkinson's disease in parallel with improvement in motor …

AA Kühn, F Kempf, C Brücke, LG Doyle… - Journal of …, 2008 - Soc Neuroscience
High-frequency stimulation (HFS) of the subthalamic nucleus (STN) is a well-established
therapy for patients with severe Parkinson9s disease (PD), but its mechanism of action is …

Translational principles of deep brain stimulation

ML Kringelbach, N Jenkinson, SLF Owen… - Nature Reviews …, 2007 - nature.com
Deep brain stimulation (DBS) has shown remarkable therapeutic benefits for patients with
otherwise treatment-resistant movement and affective disorders. This technique is not only …

Pathophysiology of parkinsonism

A Galvan, T Wichmann - Clinical neurophysiology, 2008 - Elsevier
The motor signs of Parkinson's disease are thought to result in large part from a reduction of
the level of dopamine in the basal ganglia. Over the last few years, many of the functional …

Deep brain stimulation can suppress pathological synchronisation in parkinsonian patients

A Eusebio, W Thevathasan, LD Gaynor… - Journal of Neurology …, 2011 - jnnp.bmj.com
Background Although deep brain stimulation (DBS) of the subthalamic nucleus (STN) is a
highly effective therapeutic intervention in severe Parkinson's disease, its mechanism of …