Mechanisms of deep brain stimulation
TM Herrington, JJ Cheng… - Journal of …, 2016 - journals.physiology.org
Deep brain stimulation (DBS) is widely used for the treatment of movement disorders
including Parkinson's disease, essential tremor, and dystonia and, to a lesser extent, certain …
including Parkinson's disease, essential tremor, and dystonia and, to a lesser extent, certain …
Cellular, molecular, and clinical mechanisms of action of deep brain stimulation—a systematic review on established indications and outlook on future developments
Deep brain stimulation (DBS) has been successfully used to treat movement disorders, such
as Parkinson's disease, for more than 25 years and heralded the advent of electrical …
as Parkinson's disease, for more than 25 years and heralded the advent of electrical …
History, applications, and mechanisms of deep brain stimulation
S Miocinovic, S Somayajula, S Chitnis… - JAMA neurology, 2013 - jamanetwork.com
Deep brain stimulation (DBS) is an effective surgical treatment for medication-refractory
hypokinetic and hyperkinetic movement disorders, and it is being explored for a variety of …
hypokinetic and hyperkinetic movement disorders, and it is being explored for a variety of …
Pathological synchronization in Parkinson's disease: networks, models and treatments
Parkinson's disease is a common and disabling disorder of movement owing to
dopaminergic denervation of the striatum. However, it is still unclear how this denervation …
dopaminergic denervation of the striatum. However, it is still unclear how this denervation …
Normal and pathological oscillatory communication in the brain
A Schnitzler, J Gross - Nature reviews neuroscience, 2005 - nature.com
The huge number of neurons in the human brain are connected to form functionally
specialized assemblies. The brain's amazing processing capabilities rest on local …
specialized assemblies. The brain's amazing processing capabilities rest on local …
Deep brain stimulation
JS Perlmutter, JW Mink - Annu. Rev. Neurosci., 2006 - annualreviews.org
Deep brain stimulation (DBS) has provided remarkable benefits for people with a variety of
neurologic conditions. Stimulation of the ventral intermediate nucleus of the thalamus can …
neurologic conditions. Stimulation of the ventral intermediate nucleus of the thalamus can …
High-frequency stimulation of the subthalamic nucleus suppresses oscillatory β activity in patients with Parkinson's disease in parallel with improvement in motor …
AA Kühn, F Kempf, C Brücke, LG Doyle… - Journal of …, 2008 - Soc Neuroscience
High-frequency stimulation (HFS) of the subthalamic nucleus (STN) is a well-established
therapy for patients with severe Parkinson9s disease (PD), but its mechanism of action is …
therapy for patients with severe Parkinson9s disease (PD), but its mechanism of action is …
Translational principles of deep brain stimulation
Deep brain stimulation (DBS) has shown remarkable therapeutic benefits for patients with
otherwise treatment-resistant movement and affective disorders. This technique is not only …
otherwise treatment-resistant movement and affective disorders. This technique is not only …
Pathophysiology of parkinsonism
A Galvan, T Wichmann - Clinical neurophysiology, 2008 - Elsevier
The motor signs of Parkinson's disease are thought to result in large part from a reduction of
the level of dopamine in the basal ganglia. Over the last few years, many of the functional …
the level of dopamine in the basal ganglia. Over the last few years, many of the functional …
Deep brain stimulation can suppress pathological synchronisation in parkinsonian patients
A Eusebio, W Thevathasan, LD Gaynor… - Journal of Neurology …, 2011 - jnnp.bmj.com
Background Although deep brain stimulation (DBS) of the subthalamic nucleus (STN) is a
highly effective therapeutic intervention in severe Parkinson's disease, its mechanism of …
highly effective therapeutic intervention in severe Parkinson's disease, its mechanism of …