Genetic and genomic techniques have proven incredibly powerful for identifying and
studying molecular players implicated in the epigenetic regulation of DNA-templated …

The ability to manipulate the chemical composition of proteins and peptides has been
central to the development of improved polypeptide-based therapeutics and has enabled …

Recent studies have identified serotonylation of glutamine-5 on histone H3 (H3Q5ser) as a
novel posttranslational modification (PTM) associated with active transcription. While …

Reversible modification of the histone H3 N-terminal tail is critical in regulating the chromatin
structure, gene expression, and cell states, while its dysregulation contributes to disease …

Nucleosomes constitute the fundamental building blocks of chromatin. They are comprised
of DNA wrapped around a histone octamer formed of two copies each of the four core …

Histone deacylases are erasers of N ε-acyl-lysine post-translational modifications and have
been targeted for decades for the treatment of cancer, neurodegeneration and other …

CD Chromodomain CDK1 Cyclin-abhängige Kinase 1 CNV Copy number variations CPC
Chromosomal passenger complex CR Complete Remission CSC Cancer stem cells CSD …