Hypohydration, defined as a state of low body water, increases thirst sensations, arginine
vasopressin release, and elicits renin–angiotensin–aldosterone system activation to …

Erythrocytosis, or increased production of red blood cells, is one of the most well-
documented physiological traits that varies within and among in high-altitude populations …

Cerebral hypoxic vasodilation is poorly understood in humans, which undermines the
development of therapeutics to optimize cerebral oxygen delivery. Across four investigations …

Oxygen is vital for cellular metabolism; therefore, the hypoxic conditions encountered at high
altitude affect all physiological functions. Acute hypoxia activates the adrenergic system and …

Exposure to chronic hypobaric hypoxia imposes a significant physiological burden to more
than 80 million humans living above 2500 m throughout the world. Among them, 50 000 live …

Lowlanders sojourning for more than 1 day at high altitude (HA) experience a reduction in
plasma volume (PV) that increases haemoglobin concentration and thus restores arterial …

High‐altitude (HA) hypoxia may alter the structural–functional integrity of the neurovascular
unit (NVU). Herein, we compared male lowlanders (n= 9) at sea level (SL) and after 14 days …

High-altitude (> 2,500 m) exposure results in increased muscle sympathetic nervous activity
(MSNA) in acclimatizing lowlanders. However, little is known about how altitude affects …

The diagnosis of chronic mountain sickness (CMS) is based on a score including 7 clinical
features (breathlessness, sleep disturbance, cyanosis, venous dilatation, paresthesia …

This pre-eminent work has developed over six editions in response to man's attempts to
climb higher and higher unaided, and to spend more time at altitude for both work and …