Tumour-associated macrophages are an essential component of the tumour
microenvironment and have a role in the orchestration of angiogenesis, extracellular matrix …

Complement has long been considered a key innate immune effector system that mediates
host defence and tissue homeostasis. Yet, growing evidence has illuminated a broader …

Synergistically improving T-cell responsiveness is promising for favorable therapeutic
outcomes in immunologically cold tumors, yet current treatments often fail to induce a …

Neutrophils are expanded and abundant in cancer-bearing hosts. Under the influence of
CXCR1 and CXCR2 chemokine receptor agonists and other chemotactic factors produced …

Dissecting and understanding the cancer ecosystem, especially that around the tumor
margins, which have strong implications for tumor cell infiltration and invasion, are essential …

The tumour microenvironment (TME) highly influences the growth and spread of tumours,
thus impacting the patient's clinical outcome. In this context, the complement system plays a …

Background Our previous work showed that the anti-TGF-β/PD-L1 bispecific antibody
YM101 effectively overcame anti-PD-L1 resistance in immune-excluded tumor models …

The COVID-19 pandemic caused much illness, many deaths, and profound disruption to
society. The production of 'safe and effective'vaccines was a key public health target. Sadly …

Identifying factors underlying resistance to immune checkpoint therapy (ICT) is still
challenging. Most cancer patients do not respond to ICT and the availability of the predictive …

Cancer treatment has been advanced with the advent of immune checkpoint inhibitors (ICIs)
exemplified by anti-cytotoxic T-lymphocyte-associated protein 4 (CTLA-4), anti-programmed …