The histone variant H2A. Z is involved in several processes such as transcriptional control,
DNA repair, regulation of centromeric heterochromatin and, not surprisingly, is implicated in …

Histones are integral components of eukaryotic chromatin that have a pivotal role in the
organization and function of the genome. The dynamic regulation of chromatin involves the …

The Polycomb repressive system is an essential chromatin-based regulator of gene
expression. Despite being extensively studied, how the Polycomb system selects its target …

How different intrinsic sequence variations and regulatory modifications of histones combine
in nucleosomes remain unclear. To test the importance of histone variants in the …

Epithelial-mesenchymal transition (EMT) is a developmental process hijacked by cancer
cells to modulate proliferation, migration, and stress response. Whereas kinase signaling is …

Bromodomain and extraterminal domain inhibitors (BETi) represent promising therapeutic
agents for metastatic melanoma, yet their mechanism of action remains unclear. Here we …

Bromodomain and extraterminal motif (BET) proteins are pharmacologic targets for the
treatment of diverse diseases, yet the roles of individual BET family members remain …

One in four women suffers from uterine leiomyomas (ULs)—benign tumours of the uterine
wall, also known as uterine fibroids—at some point in premenopausal life. ULs can cause …

Abstract H2A. Z variant has emerged as a critical player in regulating plant responses to
environment; however, the mechanism by which H2A. Z mediates this regulation remains …

Pluripotent stem cells give rise to all cells of the adult organism, making them an invaluable
tool in regenerative medicine. In response to differentiation cues, they can activate markedly …