During an infection, T cells can differentiate into multiple types of effector and memory T
cells, which help to mediate pathogen clearance and provide long-term protective immunity …

The ability to develop and sustain populations of memory T cells after infection or
immunization is a hallmark of the adaptive immune response and a basis for protective …

Summary T cell factor 1 (TCF-1) is a transcription factor known to act downstream of the
canonical Wnt pathway and is essential for normal T cell development. However, its …

Summary Interleukin (IL)-2 and inflammation regulate effector and memory cytolytic T-
lymphocyte (CTL) generation during infection. We demonstrate a complex interplay between …

Localization of memory CD8+ T cells to lymphoid or peripheral tissues is believed to
correlate with proliferative capacity or effector function. Here we demonstrate that the …

During acute infections, a small population of effector CD8+ T cells evades terminal
differentiation and survives as long-lived memory T cells. We demonstrate that the …

Heterogeneity is a hallmark of the adaptive immune system. This is most evident in the
enormous diversity of B and T cell antigen receptors. There is also heterogeneity within …

Immunological memory is a cardinal feature of adaptive immunity. We are now beginning to
elucidate the mechanisms that govern the formation of memory T cells and their ability to …

In response to infection, T cells adopt a range of differentiation states, creating numerous
heterogeneous subsets that exhibit different phenotypes, functions, and migration patterns …

Adoptive transfer of naturally occurring or genetically engineered T cells is an effective
treatment for certain haematological malignancies, such as non-Hodgkin lymphoma and …