The proteolytic regulation of virus cell entry by furin and other proprotein convertases
G Izaguirre - Viruses, 2019 - mdpi.com
A wide variety of viruses exploit furin and other proprotein convertases (PCs) of the
constitutive protein secretion pathway in order to regulate their cell entry mechanism and …
constitutive protein secretion pathway in order to regulate their cell entry mechanism and …
Peptidomimetics in cancer targeting
The low efficiency of treatment strategies is one of the main obstacles to developing cancer
inhibitors. Up to now, various classes of therapeutics have been developed to inhibit cancer …
inhibitors. Up to now, various classes of therapeutics have been developed to inhibit cancer …
Combining flavin photocatalysis with parallel synthesis: a general platform to optimize peptides with non-proteinogenic amino acids
JR Immel, M Chilamari, S Bloom - Chemical Science, 2021 - pubs.rsc.org
Most peptide drugs contain non-proteinogenic amino acids (NPAAs), born out through
extensive structure–activity relationship (SAR) studies using solid-phase peptide synthesis …
extensive structure–activity relationship (SAR) studies using solid-phase peptide synthesis …
Therapeutic uses of furin and its inhibitors: a patent review
Introduction: Since the discovery of furin, numerous reports have studied its role in health
and diseases, including cancer, inflammatory and infectious diseases. This interest has led …
and diseases, including cancer, inflammatory and infectious diseases. This interest has led …
Novel furin inhibitors with potent anti‐infectious activity
K Hardes, GL Becker, Y Lu, SO Dahms… - …, 2015 - Wiley Online Library
New peptidomimetic furin inhibitors with unnatural amino acid residues in the P3 position
were synthesized. The most potent compound 4‐guanidinomethyl‐phenylacteyl‐Arg‐Tle …
were synthesized. The most potent compound 4‐guanidinomethyl‐phenylacteyl‐Arg‐Tle …
PACE4 undergoes an oncogenic alternative splicing switch in cancer
Inhibition of PACE4, a proprotein convertase that is overexpressed in prostate cancer, has
been shown to block cancer progression in an androgen-independent manner. However …
been shown to block cancer progression in an androgen-independent manner. However …
Discovery of novel Thieno [2, 3-d] imidazole derivatives as agonists of human STING for antitumor immunotherapy using systemic administration
J Niu, H Bai, Z Li, Y Gao, Y Zhang, X Wang… - European Journal of …, 2022 - Elsevier
The activation of stimulator of interferon genes (STING) signaling pathways plays an
important role in the innate immune response. Although several STING agonists have been …
important role in the innate immune response. Although several STING agonists have been …
Optimization of Substrate‐Analogue Furin Inhibitors
T Ivanova, K Hardes, S Kallis, SO Dahms… - …, 2017 - Wiley Online Library
The proprotein convertase furin is a potential target for drug design, especially for the
inhibition of furin‐dependent virus replication. All effective synthetic furin inhibitors identified …
inhibition of furin‐dependent virus replication. All effective synthetic furin inhibitors identified …
Comparative host–pathogen protein–protein interaction analysis of recent coronavirus outbreaks and important host targets identification
AA Khan, Z Khan - Briefings in Bioinformatics, 2021 - academic.oup.com
Last two decades have witnessed several global infectious outbreaks. Among these,
coronavirus is identified as a prime culprit ranging from its involvement in severe acute …
coronavirus is identified as a prime culprit ranging from its involvement in severe acute …
[HTML][HTML] PACE4 inhibitors and their peptidomimetic analogs block prostate cancer tumor progression through quiescence induction, increased apoptosis and impaired …
Prostate cancer is the leading cancer in North American men. Current pharmacological
treatments are limited to anti-androgen strategies and the development of new therapeutic …
treatments are limited to anti-androgen strategies and the development of new therapeutic …