Role of RhoA/ROCK signaling in Alzheimer's disease
RL Cai, YY Wang, ZT Huang, Q Zou, YS Pu… - Behavioural brain …, 2021 - Elsevier
Rho-associated coiled-coil kinase (ROCK), a serine/threonine kinase regulated by the small
GTPase RhoA, is involved in regulating cell migration, proliferation, and survival. Numerous …
GTPase RhoA, is involved in regulating cell migration, proliferation, and survival. Numerous …
Genome-wide meta-analysis, fine-mapping and integrative prioritization implicate new Alzheimer's disease risk genes
J Schwartzentruber, S Cooper, JZ Liu… - Nature …, 2021 - nature.com
Genome-wide association studies have discovered numerous genomic loci associated with
Alzheimer's disease (AD); yet the causal genes and variants are incompletely identified. We …
Alzheimer's disease (AD); yet the causal genes and variants are incompletely identified. We …
Multi-ancestry eQTL meta-analysis of human brain identifies candidate causal variants for brain-related traits
While large-scale, genome-wide association studies (GWAS) have identified hundreds of
loci associated with brain-related traits, identification of the variants, genes and molecular …
loci associated with brain-related traits, identification of the variants, genes and molecular …
An APP ectodomain mutation outside of the Aβ domain promotes Aβ production in vitro and deposition in vivo
Familial Alzheimer's disease (FAD)–linked mutations in the APP gene occur either within the
Aβ-coding region or immediately proximal and are located in exons 16 and 17, which …
Aβ-coding region or immediately proximal and are located in exons 16 and 17, which …
Trans-ethnic eQTL meta-analysis of human brain reveals regulatory architecture and candidate causal variants for brain-related traits
While large-scale genome-wide association studies (GWAS) have identified hundreds of loci
associated with neuropsychiatric and neurodegenerative traits, identifying the variants …
associated with neuropsychiatric and neurodegenerative traits, identifying the variants …
Genome-Wide Association Study of Histopathological Quantification Methods in Primary Age-Related Tauopathy
BM Babrowicz - 2024 - search.proquest.com
Alzheimer's disease (AD) is characterized by beta-amyloid (Aß) plaques and
hyperphosphorylated tau containing neurofibrillary tangles (NFTs) throughout the brain. In …
hyperphosphorylated tau containing neurofibrillary tangles (NFTs) throughout the brain. In …
Die Rolle von Nicastrin in der Pigmentierung
MA Hermasch - 2022 - ediss.uni-goettingen.de
Die Pigmentierung und deren Regulation ist ein komplexer biologischer Prozess, der von
verschiedenen Faktoren beeinflusst wird. In diesem Rahmen wird der resultierende …
verschiedenen Faktoren beeinflusst wird. In diesem Rahmen wird der resultierende …
Genome-Wide Association Study of Dementia in a Community-Based Sample of Oldest-Old
JD Harper - 2021 - search.proquest.com
Abstract Background and Public Health Significance: Dementia broadly describes
conditions that affect a person's memory, cognition, and behavior with Alzheimer's disease …
conditions that affect a person's memory, cognition, and behavior with Alzheimer's disease …
Trans-ethnic eQTL meta-analysis of human brain reveals regulatory architecture and candidate causal variants for brain-related traits
While large-scale genome-wide association studies (GWAS) have identified hundreds of loci
associated with neuropsychiatric and neurodegenerative traits, identifying the variants …
associated with neuropsychiatric and neurodegenerative traits, identifying the variants …