MetaCompare 2.0: Differential ranking of ecological and human health resistome risks

MA Rumi, M Oh, BC Davis, CL Brown… - FEMS Microbiology …, 2024 - academic.oup.com
While numerous environmental factors contribute to the spread of antibiotic resistance
genes (ARGs), quantifying their relative contributions remains a fundamental challenge …

Genomic representativeness and chimerism in large collections of SAGs and MAGs of marine prokaryoplankton

T Chang, GS Gavelis, JM Brown, R Stepanauskas - Microbiome, 2024 - Springer
Abstract Background Single amplified genomes (SAGs) and metagenome-assembled
genomes (MAGs) are the predominant sources of information about the coding potential of …

Using genomics to explore the epidemiology of vancomycin resistance in a sewage system

EEB Jensen, S Otani, I Liachko, B Auch… - Microbiology …, 2024 - journals.asm.org
VanHAX-mediated glycopeptide resistance has been consistently high in one of the three
main sewer systems in Copenhagen, Lynetten, for+ 20 years. To explore this for other …

[HTML][HTML] Reference-free structural variant detection in microbiomes via long-read coassembly graphs

KD Curry, FB Yu, SE Vance, S Segarra, D Bhaya… - bioRxiv, 2024 - ncbi.nlm.nih.gov
Bacterial genome dynamics are vital for understanding the mechanisms underlying
microbial adaptation, growth, and their broader impact on host phenotype. Structural …

Small amounts of misassembly can have disproportionate effects on pangenome-based metagenomic analyses

SN Majernik, L Beaver, PH Bradley - bioRxiv, 2024 - biorxiv.org
Individual genes from microbiomes can drive host-level phenotypes. To help identify such
candidate genes, several recent tools estimate microbial gene copy numbers directly from …

Development and Application of Targeted DNA Sequencing Tools to Profile Microbiome-wide Antimicrobial Resistance and Pathogens of Public Health Importance

IB Slizovskiy - 2024 - search.proquest.com
Antimicrobial resistance (AMR) poses critical health challenges as drivers of frequent and
severe global outbreaks. In the US alone, AMR accounts for one infection every eleven …