Among the different possible cyclizations leading to nitrogen-containing heterocycles,
iminium ion cyclization is a widely used process exemplified by some very famous, and old …

The development of methods for the asymmetric synthesis of chiral compounds has been an
area of intense research over the last decade. 1 The interest in the preparation of chiral …

Stereoselective synthesis concerns the creation of new stereogenic centers (throughout this
review the desig-nation “stereocenter" will be used) by transformation of a prochiral group …

Covers important name reactions relevant to heterocyclic chemistry The field of heterocyclic
chemistry has long presented a special challenge for chemists. Because of the enormous …

Asymmetric Synthesis of Natural Products Fully updated learning resource covering the
concept of using natural product chemistry for strategies in asymmetric synthesis The third …

An investigation of the mechanism of benzoic acid/thiourea co-catalysis in the asymmetric
Pictet–Spengler reaction is reported. Kinetic, computational, and structure–activity …

Pictet-Spengler reactions are extensively utilized in the synthesis of various indole alkaloids.
However, their mechanisms have been a controversial research topic. The role of …

P-Carbolines are widely distributed in nature, the basic ring system 1 (Fig. 1) being found in
several families of natural products.'For example, some of the simplest P-carboline natural …

The factors that control the relative and absolute stereochemistry of 1, 3-disubstituted and 1,
2, 3-trisubstituted tetrahydro-β-carbolines formed via the Pictet–Spengler reaction are …

For the last-100 years, the Pictet-Spengler (PS) reaction, first reported by Pictet and
Spengler in 1911, l has been an important reaction for CC bond formation leading to ring …