Quaternary ammonium salts of chitosan. A critical overview on the synthesis and properties generated by quaternization

BI Andreica, X Cheng, L Marin - European Polymer Journal, 2020 - Elsevier
The quaternary ammonium salts of chitosan are water soluble derivatives which keep the
promise for real life applications in a large realm of biomedical fields, such as antimicrobial …

Chitosan-based colloidal polyelectrolyte complexes for drug delivery: a review

D Wu, L Zhu, Y Li, X Zhang, S Xu, G Yang… - Carbohydrate polymers, 2020 - Elsevier
Polyelectrolyte complexes (PECs) as safe drug delivery carriers, are spontaneously formed
by mixing the oppositely charged polyelectrolyte solutions in water without using organic …

[HTML][HTML] Chitosan based self-assembled nanoparticles in drug delivery

JP Quiñones, H Peniche, C Peniche - Polymers, 2018 - mdpi.com
Chitosan is a cationic polysaccharide that is usually obtained by alkaline deacetylation of
chitin poly (N-acetylglucosamine). It is biocompatible, biodegradable, mucoadhesive, and …

[HTML][HTML] The application of mucoadhesive chitosan nanoparticles in nasal drug delivery

S Shim, HS Yoo - Marine drugs, 2020 - mdpi.com
Mucosal delivery of antigens can induce both humoral and cellular immune responses.
Particularly, the nasal cavity is a strongly inductive site for mucosal immunity among several …

Development of mutlifunctional nanoparticles self-assembled from trimethyl chitosan and fucoidan for enhanced oral delivery of insulin

LC Tsai, CH Chen, CW Lin, YC Ho, FL Mi - International journal of …, 2019 - Elsevier
Oral administration is a highly attractive approach for the delivery of protein drugs. However,
oral protein therapeutics typically exhibit extremely poor bioavailability due to the harsh …

Construction of self-assembled polyelectrolyte complex hydrogel based on oppositely charged polysaccharides for sustained delivery of green tea polyphenols

X Hu, Y Wang, L Zhang, M Xu - Food chemistry, 2020 - Elsevier
In this study, we have developed a novel polyelectrolyte complex (PEC) hydrogel that could
be easily prepared by self-assembly of two food-grade polysaccharides salecan and N, N, N …

N, N, N-Trimethyl chitosan: An advanced polymer with myriad of opportunities in nanomedicine

AD Kulkarni, HM Patel, SJ Surana, YH Vanjari… - Carbohydrate …, 2017 - Elsevier
Abstract N, N, N-trimethyl chitosan (TMC), a quaternized hydrophilic derivative of chitosan
(CHT), outperformed the well-known solubility issues raised by CHT. The excellent …

[HTML][HTML] Challenges in developing of chitosan–based polyelectrolyte complexes as a platform for mucosal and skin drug delivery

J Potaś, E Szymańska, K Winnicka - European Polymer Journal, 2020 - Elsevier
Chitosan, a biocompatible positively charged polysaccharide from natural origin, is regarded
as a promising compound in medical and pharmaceutical technology. However, despitehigh …

Green synthesis of quaternized chitosan/silver nanocomposites for targeting mycobacterium tuberculosis and lung carcinoma cells (A-549)

MM Abdel-Aziz, MHA Elella, RR Mohamed - International journal of …, 2020 - Elsevier
Lung cancer (LC) is the most-deadly type of cancer representing a major public health
problem worldwide. Tuberculosis TB is another infectious disease influencing lungs that …

Chitosan biopolymer, its derivatives and potential applications in nano-therapeutics: A comprehensive review

M Mukhtar, E Fényes, C Bartos, M Zeeshan… - European Polymer …, 2021 - Elsevier
Chitosan (CS) is a natural biopolymer used frequently in drug delivery because of its
biodegradability and biocompatibility. Several derivatives of CS have also been synthesized …