Synthetic strategies applicable in the synthesis of privileged scaffold: 1, 4-benzodiazepine

N Kaur, D Kishore - Synthetic Communications, 2014 - Taylor & Francis
The development of new synthetic approaches to the 1, 4-benzodiazepine ring system and
their further elaboration have provided access to a broad range of functionalized derivatives …

Isatoic anhydride: a fascinating and basic molecule for the synthesis of substituted quinazolinones and benzo di/triazepines

Z Tashrifi… - Current Organic …, 2019 - ingentaconnect.com
This review article is focused on the synthesis of compounds with quinazolinones and benzo
di/triazepine scaffolds. These invaluable derivatives are of great interest in medicinal and …

Design, synthesis and biological evaluation of 1, 4-benzodiazepine-2, 5-dione-based HDAC inhibitors

L Loudni, J Roche, V Potiron, J Clarhaut… - Bioorganic & medicinal …, 2007 - Elsevier
New histone deacetylase inhibitors have been synthesized and evaluated for their activity
against non-small lung cancer cell line H661. These compounds have been designed with …

1, 4‐Thienodiazepine‐2, 5‐diones via MCR (II): Scaffold Hopping by Gewald and Ugi‐Deprotection‐Cyclization Strategy

Y Huang, A Dömling - Chemical biology & drug design, 2010 - Wiley Online Library
A second scaffold of 1, 4‐thienodiazepine‐2, 5‐diones was discovered and is synthetically
accessible from Gewald 2‐aminothiophenes via Ugi‐Deprotection‐Cyclization (UDC) …

Solvent effect dependence of the dual fluorescence of N, N-dimethylbenzodiazepine

A Elassyry, B Benali, Z Lazar, K Elblidi… - Journal of molecular …, 2006 - Elsevier
N, N-dimethylbenzodiazepine exhibits two fluorescence emission (Fa and Fn) bands in
protic solvents and one (Fn band) in aprotic solvents. These bands are assigned on the …

[PDF][PDF] Quantum chemical study by Density Functional Theory (DFT) of some benzodiazepine derivatives

A El Assyry, B Benali, A Boucetta… - J Mater Environ …, 2014 - jmaterenvironsci.com
Geometries and properties depending on the electron density for some benzodiazepine
derivatives are optimized and obtained by RHF/STO-3G quantum calculations. The results …

Crystal structure of benzodiazepin-2, 4-dione

P Négrier, D Mondieig, JM Léger, B Benali… - Analytical Sciences: X …, 2006 - jstage.jst.go.jp
The single-crystal structure of benzodiazepin-2, 4-dione (C9H8N2O2) was determined at
room temperature. The compound is monoclinic, P21/m with Z= 2, the molecule is …

Crystal Structure of 1, 5-Dimethyl-benzodiazepin-2, 4-dione

D Mondieig, P Négrier, JM Léger, B Benali… - Analytical Sciences: X …, 2005 - jstage.jst.go.jp
The single-crystal structure of 1, 5-dimethylbenzodiazepin-2, 4-dione (C11H12N2O2) was
determined at room temperature. The compound is orthorhombic, Pnma with Z= 4; the …

Spectroscopy of Benzodiazepine‐2, 4‐Dione in Solution

B Benali, A El Assyry, A Boucetta, Z Lazar… - Spectroscopy …, 2007 - Taylor & Francis
The absorption and emission spectra of benzodiazepine‐2, 4‐dione in solution were
measured at room temperature. Assignments of the electronic transitions involved are …

Improved method for microwave-assisted synthesis of benzodiazepine-2, 5-diones from isatoic anhydrides mediated by glacial acetic acid

ADL Cruz, CA Vega-Acevedo, IA Rivero… - Journal of the Brazilian …, 2018 - SciELO Brasil
An improved and simpler method for the synthesis of benzodiazepin-2, 5-diones and 7-
iodobenzodiazepin-2, 5-diones catalyzed by glacial acetic acid using isatoic anhydride and …