T cells are crucial for immune functions to maintain health and prevent disease. T cell
development occurs in a stepwise process in the thymus and mainly generates CD4+ and …

The proper transfer of genetic information from DNA to RNA to protein is essential for cell-
fate control, development, and health. Methylation of DNA, RNAs, histones, and non-histone …

CD8+ T cells are essential lymphocytes with cytotoxic properties for antitumor
immunotherapy. However, during chronic infection or tumorigenesis, these cells often …

Chronic antigen stimulation is thought to generate dysfunctional CD8 T cells. Here, we
identify a CD8 T cell subset in the bone marrow tumor microenvironment that, despite an …

Cancer immunotherapy using immune-checkpoint inhibitors (ICIs) has revolutionized the
field of cancer treatment; however, ICI efficacy is constrained by progressive dysfunction of …

Memory CD8+ T cells play a crucial role in infection and cancer and mount rapid responses
to repeat antigen exposure. Although memory cell transcriptional programmes have been …

Breast cancer is the most common cancer type and ranks the second in cancer-related
deaths in women. However, the relationship between inflammation-related gene signatures …

Prolidase deficiency (PD) is a multisystem disorder caused by mutations in the PEPD gene,
which encodes a ubiquitously expressed metallopeptidase essential for the hydrolysis of …

DNA damage-repair machinery participates in maintaining genomic integrity and affects
tumorigenesis. Molecular signatures based on DNA damage-repair-related genes (DRGs) …

Osteoarthritis (OA) represents a multifaceted pathology characterized by intricate signaling
across various joint tissues, where the sub-synovial adipose tissue (ssAT) has been …