Alternative pre-mRNA splicing increases the complexity of the proteome that can be
generated from the available genomic coding sequences. Dysregulation of the splicing …

Caenorhabditis elegans is an exceptionally valuable model for aging research because of
many advantages, including its genetic tractability, short lifespan, and clear age‐dependent …

Translation is pervasive outside of canonical coding regions, occurring in long noncoding
RNAs, canonical untranslated regions and introns,,–, especially in ageing …

Abstract Insulin/IGF-1 Signaling (IIS) is known to constrain longevity by inhibiting the
transcription factor FOXO. How phosphorylation mediated by IIS kinases regulates lifespan …

Caenorhabditis elegans has been used as a major model organism to identify genetic
factors that regulate organismal aging and longevity. Insulin/insulin-like growth factor 1 (IGF …

Aging is associated with gradual deterioration of physiological and biochemical functions,
including cognitive decline. Transcriptome profiling of brain samples from individuals of …

The proper maintenance of mRNA quality that is regulated by diverse surveillance pathways
is essential for cellular homeostasis and is highly conserved among eukaryotes. Here, we …

Low temperatures delay aging and promote longevity in many organisms. However, the
metabolic and homeostatic aspects of low-temperature–induced longevity remain poorly …

Aging-induced functional and phenotypic alterations of the vasculature (eg, endothelial
dysfunction, oxidative stress) have a central role in morbidity and mortality of older adults. It …

Aging is associated with changes in a variety of biological processes at the transcriptomic
level, including gene expression. Two types of aging occur during a lifetime: chronological …