[HTML][HTML] Exploring the mechanisms behind long noncoding RNAs and cancer

MM Balas, AM Johnson - Non-coding RNA research, 2018 - Elsevier
Over the past decade, long noncoding RNAs (lncRNAs) have been identified as significant
players in gene regulation. They are often differentially expressed and widely-associated …

The cell-line-derived subcutaneous tumor model in preclinical cancer research

SM Stribbling, AJ Ryan - Nature Protocols, 2022 - nature.com
Tumor-bearing experimental animals are essential for preclinical cancer drug development.
A broad range of tumor models is available, with the simplest and most widely used …

HOTAIR LncRNA: a novel oncogenic propellant in human cancer

T Rajagopal, S Talluri, RL Akshaya, NR Dunna - Clinica chimica acta, 2020 - Elsevier
Long non-coding RNAs (lncRNAs) are an important novel class of non-coding RNAs having
lengths of 200 nucleotides and low expression. The HOX Transcript Antisense Intergenic …

The role of epigenetic modifications in human cancers and the use of natural compounds as epidrugs: Mechanistic pathways and pharmacodynamic actions

A Bouyahya, H Mechchate, L Oumeslakht, I Zeouk… - Biomolecules, 2022 - mdpi.com
Cancer is a complex disease resulting from the genetic and epigenetic disruption of normal
cells. The mechanistic understanding of the pathways involved in tumor transformation has …

Noncoding RNAs in Alzheimer's disease

ML Idda, R Munk, K Abdelmohsen… - Wiley Interdisciplinary …, 2018 - Wiley Online Library
Alzheimer's disease (AD) is a progressive neurodegenerative disorder and the main cause
of dementia among the elderly worldwide. Despite intense efforts to develop drugs for …

Long non-coding RNA (lncRNA) roles in cell biology, neurodevelopment and neurological disorders

V Aliperti, J Skonieczna, A Cerase - Non-coding RNA, 2021 - mdpi.com
Development is a complex process regulated both by genetic and epigenetic and
environmental clues. Recently, long non-coding RNAs (lncRNAs) have emerged as key …

Long noncoding RNAs and circular RNAs in autoimmune diseases

V Lodde, G Murgia, ER Simula, M Steri, M Floris… - Biomolecules, 2020 - mdpi.com
Immune responses are essential for the clearance of pathogens and the repair of injured
tissues; however, if these responses are not properly controlled, autoimmune diseases can …

Long non-coding RNAs in regulation of adipogenesis and adipose tissue function

T Squillaro, G Peluso, U Galderisi, G Di Bernardo - Elife, 2020 - elifesciences.org
Complex interaction between genetics, epigenetics, environment, and nutrition affect the
physiological activities of adipose tissues and their dysfunctions, which lead to several …

Epigenetics in the uterine environment: how maternal diet and ART may influence the epigenome in the offspring with long-term health consequences

I Peral-Sanchez, B Hojeij, DA Ojeda… - Genes, 2021 - mdpi.com
The societal burden of non-communicable disease is closely linked with environmental
exposures and lifestyle behaviours, including the adherence to a poor maternal diet from the …

DNA methyltransferases: from evolution to clinical applications

VM Del Castillo Falconi, K Torres-Arciga… - International journal of …, 2022 - mdpi.com
DNA methylation is an epigenetic mark that living beings have used in different
environments. The MTases family catalyzes DNA methylation. This process is conserved …