The transmission of a complete set of chromosomes to daughter cells during cell division is
vital for development and tissue homeostasis. The spindle assembly checkpoint (SAC) …

Kinetochores are large protein assemblies that connect chromosomes to microtubules of the
mitotic and meiotic spindles in order to distribute the replicated genome from a mother cell to …

The spindle assembly checkpoint is a safeguard mechanism that coordinates cell-cycle
progression during mitosis with the state of chromosome attachment to the mitotic spindle …

Eukaryotic cilia and flagella are evolutionarily conserved organelles that protrude from the
cell surface. The unique location and properties of cilia allow them to function in vital …

Coiled‐coils are found in proteins throughout all three kingdoms of life. Coiled‐coil domains
of some proteins are almost invariant in sequence and length, betraying a structural and …

Successful cell division requires the precise and timely coordination of chromosomal,
cytoskeletal and membrane trafficking events. These processes are regulated by the …

In eukaryotes, chromosome segregation during cell division is facilitated by the kinetochore,
a multiprotein structure that is assembled on centromeric DNA. The kinetochore attaches …

Aurora B, a member of the Aurora family of serine/threonine protein kinases, is a key player
in chromosome segregation. As part of a macromolecular complex known as the …

Kinetochores are molecular machines that power chromosome segregation during the
mitotic and meiotic cell divisions of all eukaryotes. Aristotle explains how we think we have …

A critical requirement for mitosis is the distribution of genetic material to the two daughter
cells. The central player in this process is the macromolecular kinetochore structure, which …