The ADP-ribosylation factor (ARF) small GTPases regulate vesicular traffic and organelle
structure by recruiting coat proteins, regulating phospholipid metabolism and modulating the …

Bacteria and eukaryotic cells contain geometry-sensing tools in their cytosol: protein motifs
or domains that recognize the curvature, concave or convex, deep or shallow, of lipid …

Cellular versatility depends on accurate trafficking of diverse proteins to their organellar
destinations. For the secretory pathway (followed by approximately 30% of all proteins), the …

Many RNA viruses remodel intracellular membranes to generate specialized sites for RNA
replication. How membranes are remodeled and what properties make them conducive for …

The ability to visualize, track, and quantify molecules and events in living cells with high
spatial and temporal resolution is essential for understanding biological systems. Only …

Dynamin-related protein 1 (DRP1) plays an important role in mitochondrial fission at steady
state and during apoptosis. Using fluorescence recovery after photobleaching, we …

Protein traffic moving from the endoplasmic reticulum (ER) to the Golgi complex in
mammalian cells passes through the tubulovesicular membrane clusters of the ER-Golgi …

COPII and COPI mediate the formation of membrane vesicles translocating in opposite
directions within the secretory pathway. Live-cell and electron microscopy revealed a novel …

Dynamic molecular interactions are fundamental to all cellular processes. In vivo analyses of
these interactions are frequently done using fluorescence recovery after photobleaching …

Endocytosis comprises several routes of internalization. An outstanding question is whether
the caveolar and endosomal pathways intersect. Following transport of the caveolar protein …