The cellular and molecular mechanisms of vertebrate lens development
A Cvekl, R Ashery-Padan - Development, 2014 - journals.biologists.com
The ocular lens is a model system for understanding important aspects of embryonic
development, such as cell specification and the spatiotemporally controlled formation of a …
development, such as cell specification and the spatiotemporally controlled formation of a …
Ionizing radiation induced cataracts: Recent biological and mechanistic developments and perspectives for future research
EA Ainsbury, S Barnard, S Bright, C Dalke… - … Research/Reviews in …, 2016 - Elsevier
The lens of the eye has long been considered as a radiosensitive tissue, but recent research
has suggested that the radiosensitivity is even greater than previously thought. The 2012 …
has suggested that the radiosensitivity is even greater than previously thought. The 2012 …
Pax6: a multi-level regulator of ocular development
O Shaham, Y Menuchin, C Farhy… - Progress in retinal and …, 2012 - Elsevier
Eye development has been a paradigm for the study of organogenesis, from the
demonstration of lens induction through epithelial tissue morphogenesis, to neuronal …
demonstration of lens induction through epithelial tissue morphogenesis, to neuronal …
Signaling and gene regulatory networks in mammalian lens development
Ocular lens development represents an advantageous system in which to study regulatory
mechanisms governing cell fate decisions, extracellular signaling, cell and tissue …
mechanisms governing cell fate decisions, extracellular signaling, cell and tissue …
PAX6: 25th anniversary and more to learn
A Cvekl, P Callaerts - Experimental eye research, 2017 - Elsevier
The DNA-binding transcription factor PAX6 was cloned 25 years ago by multiple teams
pursuing identification of human and mouse eye disease causing genes, cloning vertebrate …
pursuing identification of human and mouse eye disease causing genes, cloning vertebrate …
[HTML][HTML] Functional integration of eye tissues and refractive eye development: Mechanisms and pathways
Refractive eye development is a tightly coordinated developmental process. The general
layout of the eye and its various components are established during embryonic …
layout of the eye and its various components are established during embryonic …
Lens epithelial explants treated with vitreous humor undergo alterations in chromatin landscape with concurrent activation of genes associated with fiber cell …
A Upreti, SL Padula, JA Tangeman, BD Wagner… - Cells, 2023 - mdpi.com
Lens epithelial explants are comprised of lens epithelial cells cultured in vitro on their native
basement membrane, the lens capsule. Biologists have used lens epithelial explants to …
basement membrane, the lens capsule. Biologists have used lens epithelial explants to …
[HTML][HTML] The mechanism of lens placode formation: a case of matrix-mediated morphogenesis
J Huang, R Rajagopal, Y Liu, LK Dattilo, O Shaham… - Developmental …, 2011 - Elsevier
Although placodes are ubiquitous precursors of tissue invagination, the mechanism of
placode formation has not been established and the requirement of placode formation for …
placode formation has not been established and the requirement of placode formation for …
Lens development and crystallin gene expression
The eye and lens represent excellent models to understand embryonic development at
cellular and molecular levels. Initial 3D formation of the eye depends on a reciprocal …
cellular and molecular levels. Initial 3D formation of the eye depends on a reciprocal …
Stage-dependent requirement of neuroretinal Pax6 for lens and retina development
The physical contact of optic vesicle with head surface ectoderm is an initial event triggering
eye morphogenesis. This interaction leads to lens specification followed by coordinated …
eye morphogenesis. This interaction leads to lens specification followed by coordinated …