Pregnancy-induced changes to the gut microbiota drive macrophage pyroptosis and exacerbate septic inflammation

X Chen, R Wu, L Li, Y Zeng, J Chen, M Wei, Y Feng… - Immunity, 2023 - cell.com
The physiological and immune changes that occur during pregnancy are associated with
worsened disease outcomes during infection and sepsis. How these perturbations …

Mitochondrial dysfunction as a signaling target for therapeutic intervention in major neurodegenerative disease

SV Mangrulkar, NL Wankhede, MB Kale… - Neurotoxicity …, 2023 - Springer
Neurodegenerative diseases (NDD) are incurable and the most prevalent cognitive and
motor disorders of elderly. Mitochondria are essential for a wide range of cellular processes …

Navigating the Intersection: Diabetes and Alzheimer's Intertwined Relationship

MB Kale, HM Bhondge, NL Wankhede… - Ageing Research …, 2024 - Elsevier
Alzheimer's disease (AD) and Diabetes mellitus (DM) exhibit comparable
pathophysiological pathways. Genetic abnormalities in APP, PS-1, and PS-2 are linked to …

Molecular understanding of ER-MT communication dysfunction during neurodegeneration

SS Sammeta, TA Banarase, SR Rahangdale… - Mitochondrion, 2023 - Elsevier
Biological researchers are seeing organelles in a new light. These cellular entities have
been believed to be singular and distinctive structures that performed specialized purposes …

Mitophagy regulation in aging and neurodegenerative disease

TA Banarase, SS Sammeta, NL Wankhede… - Biophysical …, 2023 - Springer
Mitochondria are the primary cellular energy generators, supplying the majority of
adenosine triphosphate through oxidative phosphorylation, which is necessary for neuron …

Decoding mitochondrial quality control mechanisms: Identifying treatment targets for enhanced cellular health

NL Wankhede, SR Kopalli, MD Dhokne, DJ Badnag… - Mitochondrion, 2024 - Elsevier
Mitochondria are singular cell organelles essential for many cellular functions, which
includes responding to stress, regulating calcium levels, maintaining protein homeostasis …

Unraveling the nexus of age, epilepsy, and mitochondria: exploring the dynamics of cellular energy and excitability

W Xie, S Koppula, MB Kale, LS Ali… - Frontiers in …, 2024 - frontiersin.org
Epilepsy, a complex neurological condition marked by recurring seizures, is increasingly
recognized for its intricate relationship with mitochondria, the cellular powerhouses …

Protein research may hint at how human eggs survive for decades

C Szalinski - Proceedings of the National Academy of Sciences, 2024 - pnas.org
Human eggs, called oocytes, have a superpower: They can stay in the ovaries for decades,
from before a woman is born until she's over age 40. Most of our cells are constantly turning …

Decoding the therapeutic potential of cannabis and cannabinoids in neurological disorders

MB Kale, MD Umare, NL Wankhede… - Current …, 2024 - benthamdirect.com
For millennia, Cannabis sativa has served diverse roles, from medicinal applications to
recreational use. Despite its extensive historical use, only a fraction of its components have …

A compendium for novel marker-based breeding strategies in eggplant

L Gaccione, M Martina, L Barchi, E Portis - Plants, 2023 - mdpi.com
The worldwide production of eggplant is estimated at about 58 Mt, with China, India and
Egypt being the major producing countries. Breeding efforts in the species have mainly …