Recent technological advances have made it possible to decode DNA methylomes at single-
base-pair resolution under various physiological conditions. Many aberrant or differentially …

Here, we provide an update of our review on homeobox genes that we wrote together with
Walter Gehring in 1994. Since then, comprehensive surveys of homeobox genes have …

Zygotic genome activation (ZGA) activates the quiescent genome to enable the maternal-to-
zygotic transition,. However, the identity of transcription factors that underlie mammalian …

Protein–ligand interactions are increasingly profiled at high throughput using affinity
selection and massively parallel sequencing. However, these assays do not provide the …

The reference human genome sequence set the stage for studies of genetic variation and its
association with human disease, but epigenomic studies lack a similar reference. To …

Fetal hemoglobin (HbF, α 2 γ 2) level is genetically controlled and modifies severity of adult
hemoglobin (HbA, α 2 β 2) disorders, sickle cell disease, and β-thalassemia. Common …

Transcription factor (TF) DNA sequence preferences direct their regulatory activity, but are
currently known for only∼ 1% of eukaryotic TFs. Broadly sampling DNA-binding domain …

Knowing the sequence specificities of DNA-and RNA-binding proteins is essential for
developing models of the regulatory processes in biological systems and for identifying …

Super-enhancers (SEs) are cell-specific DNA cis-regulatory elements that can supervise the
transcriptional regulation processes of downstream genes. SEdb 2.0 (http://www. licpathway …

RNA-binding proteins are key regulators of gene expression, yet only a small fraction have
been functionally characterized. Here we report a systematic analysis of the RNA motifs …