TRAIP is a master regulator of DNA interstrand crosslink repair
RA Wu, DR Semlow, AN Kamimae-Lanning… - Nature, 2019 - nature.com
Cells often use multiple pathways to repair the same DNA lesion, and the choice of pathway
has substantial implications for the fidelity of genome maintenance. DNA interstrand …
has substantial implications for the fidelity of genome maintenance. DNA interstrand …
Replication-dependent unhooking of DNA interstrand cross-links by the NEIL3 glycosylase
During eukaryotic DNA interstrand cross-link (ICL) repair, cross-links are resolved ("
unhooked") by nucleolytic incisions surrounding the lesion. In vertebrates, ICL repair is …
unhooked") by nucleolytic incisions surrounding the lesion. In vertebrates, ICL repair is …
Formation and repair of unavoidable, endogenous interstrand cross-links in cellular DNA
Genome integrity is essential for life and, as a result, DNA repair systems evolved to remove
unavoidable DNA lesions from cellular DNA. Many forms of life possess the capacity to …
unavoidable DNA lesions from cellular DNA. Many forms of life possess the capacity to …
Mitotic CDK promotes replisome disassembly, fork breakage, and complex DNA rearrangements
DNA replication errors generate complex chromosomal rearrangements and thereby
contribute to tumorigenesis and other human diseases. One mechanism that triggers these …
contribute to tumorigenesis and other human diseases. One mechanism that triggers these …
A role for the base excision repair enzyme NEIL3 in replication-dependent repair of interstrand DNA cross-links derived from psoralen and abasic sites
Interstrand DNA–DNA cross-links are highly toxic lesions that are important in medicinal
chemistry, toxicology, and endogenous biology. In current models of replication-dependent …
chemistry, toxicology, and endogenous biology. In current models of replication-dependent …
DNA interstrand cross-links induced by the major oxidative adenine lesion 7, 8-dihydro-8-oxoadenine
AL Rozelle, Y Cheun, CK Vilas, MC Koag… - Nature …, 2021 - nature.com
Oxidative damage to DNA generates 7, 8-dihydro-8-oxoguanine (oxoG) and 7, 8-dihydro-8-
oxoadenine (oxoA) as two major lesions. Despite the comparable prevalence of these …
oxoadenine (oxoA) as two major lesions. Despite the comparable prevalence of these …
Reconsidering the chemical nature of Strand breaks derived from abasic sites in cellular DNA: evidence for 3′-glutathionylation
The hydrolytic loss of coding bases from cellular DNA is a common and unavoidable
reaction. The resulting abasic sites can undergo β-elimination of the 3′-phosphoryl group …
reaction. The resulting abasic sites can undergo β-elimination of the 3′-phosphoryl group …
Unhooking of an interstrand cross-link at DNA fork structures by the DNA glycosylase NEIL3
Interstrand DNA-DNA cross-links (ICLs) are generated by endogenous processes, drugs,
and environmental toxins. Understanding the cellular pathways by which various ICLs are …
and environmental toxins. Understanding the cellular pathways by which various ICLs are …
Unprecedented reactivity of polyamines with aldehydic DNA modifications: structural determinants of reactivity, characterization and enzymatic stability of adducts
EP Gusti Ngurah Putu, L Cattiaux… - Nucleic Acids …, 2023 - academic.oup.com
Abstract Apurinic/apyrimidinic (AP) sites, 5-formyluracil (fU) and 5-formylcytosine (fC) are
abundant DNA modifications that share aldehyde-type reactivity. Here, we demonstrate that …
abundant DNA modifications that share aldehyde-type reactivity. Here, we demonstrate that …
Structure of a Stable Interstrand DNA Cross-Link Involving a β-N-Glycosyl Linkage Between an N6-dA Amino Group and an Abasic Site
AH Kellum Jr, DY Qiu, MW Voehler, W Martin… - Biochemistry, 2020 - ACS Publications
Abasic (AP) sites are one of the most common forms of DNA damage. The deoxyribose ring
of AP sites undergoes anomerization between α and β configurations, via an electrophilic …
of AP sites undergoes anomerization between α and β configurations, via an electrophilic …