ER-phagy (reticulophagy) defines the degradation of portions of the endoplasmic reticulum
(ER) within lysosomes or vacuoles. It is part of the self-digestion (ie, autophagic) programs …

Post-translational modifications are at the apex of cellular communication and eventually
regulate every aspect of life. The identification of new post-translational modifiers is opening …

UFM1 is a member of the ubiquitin like protein family. While the enzymatic cascade of UFM1
conjugation has been elucidated in recent years, the biological function remains largely …

The Ufm1 conjugation system is a novel ubiquitin-like modification system, consisting of
Ufm1, Uba5 (E1), Ufc1 (E2) and poorly characterized E3 ligase (s). RCAD/Ufl1 (also known …

The IRE1α/XBP1 branch of unfolded protein response (UPR) pathway has a critical function
in endoplasmic reticulum (ER) expansion in plasma cells via unknown mechanisms; …

Homeostasis of the endoplasmic reticulum (ER) is essential for normal cellular functions.
Disturbance of this homeostasis causes ER stress and activates the Unfolded Protein …

Via whole-exome sequencing, we identified rare autosomal-recessive variants in UBA5 in
five children from four unrelated families affected with a similar pattern of severe intellectual …

Abstract Spinocerebellar ataxia type 1 (SCA1) is an incurable, dominantly inherited
neurodegenerative disease of the cerebellum caused by a polyglutamine-repeat expansion …

Astrocytes, initially described as merely support cells, are now known as a heterogeneous
population of cells actively involved in a variety of biological functions such as: neuronal …

Autosomal recessive cerebellar ataxia (ARCA) comprises a large and heterogeneous group
of neurodegenerative disorders. For many affected patients, the genetic cause remains …