[HTML][HTML] Adipose tissue distribution, inflammation and its metabolic consequences, including diabetes and cardiovascular disease

A Chait, LJ Den Hartigh - Frontiers in cardiovascular medicine, 2020 - frontiersin.org
Adipose tissue plays essential roles in maintaining lipid and glucose homeostasis. To date
several types of adipose tissue have been identified, namely white, brown, and beige, that …

Brown and beige adipose tissue: a novel therapeutic strategy for obesity and type 2 diabetes mellitus

L Cheng, J Wang, H Dai, Y Duan, Y An, L Shi, Y Lv… - Adipocyte, 2021 - Taylor & Francis
Mammalian adipose tissue can be divided into two major types, namely, white adipose
tissue (WAT) and brown adipose tissue (BAT). According to classical view, the main function …

Intermittent fasting promotes white adipose browning and decreases obesity by shaping the gut microbiota

G Li, C Xie, S Lu, RG Nichols, Y Tian, L Li, D Patel… - Cell metabolism, 2017 - cell.com
While activation of beige thermogenesis is a promising approach for treatment of obesity-
associated diseases, there are currently no known pharmacological means of inducing …

[HTML][HTML] The role of adipose tissue in cardiovascular health and disease

EK Oikonomou, C Antoniades - Nature Reviews Cardiology, 2019 - nature.com
Accumulating knowledge on the biology and function of the adipose tissue has led to a
major shift in our understanding of its role in health and disease. The adipose tissue is now …

The role of adipose tissue mitochondria: regulation of mitochondrial function for the treatment of metabolic diseases

JH Lee, A Park, KJ Oh, SC Lee, WK Kim… - International journal of …, 2019 - mdpi.com
Mitochondria play a key role in maintaining energy homeostasis in metabolic tissues,
including adipose tissues. The two main types of adipose tissues are the white adipose …

Aerobic exercise promotes the functions of brown adipose tissue in obese mice via a mechanism involving COX2 in the VEGF signaling pathway

P Fu, R Zhu, J Jia, Y Hu, C Wu, P Cieszczyk… - Nutrition & …, 2021 - Springer
Background High-fat diet (HFD)-induced obesity causes immune cells to infiltrate adipose
tissue, leading to chronic inflammation and metabolic syndrome. Brown adipose tissue …

The sympathetic nervous system in the 21st century: Neuroimmune interactions in metabolic homeostasis and obesity

N Martinez-Sanchez, O Sweeney, D Sidarta-Oliveira… - Neuron, 2022 - cell.com
The sympathetic nervous system maintains metabolic homeostasis by orchestrating the
activity of organs such as the pancreas, liver, and white and brown adipose tissues. From …

Mitochondria in white, brown, and beige adipocytes

M Cedikova, M Kripnerová, J Dvorakova… - Stem cells …, 2016 - Wiley Online Library
Mitochondria play a key role in energy metabolism in many tissues, including cardiac and
skeletal muscle, brain, liver, and adipose tissue. Three types of adipose depots can be …

Evidence against a beneficial effect of irisin in humans

S Raschke, M Elsen, H Gassenhuber, M Sommerfeld… - PloS one, 2013 - journals.plos.org
Brown adipose tissue has gained interest as a potential target to treat obesity and metabolic
diseases. Irisin is a newly identified hormone secreted from skeletal muscle enhancing …

[HTML][HTML] Convertible visceral fat as a therapeutic target to curb obesity

A Giordano, A Frontini, S Cinti - Nature Reviews Drug Discovery, 2016 - nature.com
New therapeutic and preventative strategies are needed to address the growing obesity
epidemic. In animal models, brown adipose tissue activation and the associated heat …