The challenges in successful vaccination against influenza using conventional approaches
lie in their variable efficacy in different age populations, the antigenic variability of the …

The human immune system comprises cellular and molecular components designed to
coordinately prevent infection while avoiding potentially harmful inflammation and …

Influenza A and B virus infections are a major cause of respiratory disease in humans and
are responsible for substantial morbidity and mortality worldwide. Vaccination against …

Background The consequences of influenza in children and adults are mainly absenteeism
from school and work. However, the risk of complications is greatest in children and people …

ABSTRACT Since 2003 (US) and 2012 (Europe) the live attenuated influenza vaccine
(LAIV) has been used as an alternative to the traditional inactivated influenza vaccines (IIV) …

Background The efficacy of inactivated influenza vaccines is known to be poor in infants and
young children. Methods We studied the effect of the adjuvant MF59, an oil-in-water …

Since the beginning in December 2019, the SARS-CoV-2 outbreak appeared to affect
mostly the adult population, sparing the vast majority of children who only showed mild …

Objective To examine whether deviation from the standard intention to treat analysis has an
influence on treatment effect estimates of randomised trials. Design Meta-epidemiological …

Please cite this paper as: Ambrose CS et al.(2011) The relative efficacy of trivalent live
attenuated and inactivated influenza vaccines in children and adults. Influenza and Other …

The innate immune pathways induced by adjuvants required to increase adaptive
responses to influenza subunit vaccines are not well characterized. We profiled different …