Aspirin resistance is the inability of aspirin to reduce platelet production of thromboxane A 2
and thereby platelet activation and aggregation. Increasing degrees of aspirin resistance …

Oral antiplatelet drugs are a cornerstone of modern pharmacotherapy in cardiovascular
atherothrombotic diseases. The efficacy of acetylsalicylic acid (ASA, aspirin) and clopidogrel …

Aims We sought to compare the results obtained from six major platelet function tests in the
assessment of the prevalence of aspirin resistance in patients with stable coronary artery …

Background—The antiplatelet effect of aspirin is attributed to platelet cyclooxygenase-1
inhibition. Controversy exists on the prevalence of platelet resistance to aspirin in patients …

Aspirin is well recognized as an effective antiplatelet drug for secondary prevention in
subjects at high risk of cardiovascular events. However, most patients receiving long-term …

Aspirin is effective in the prevention of cardiovascular events in high-risk patients. The
primary established effect of aspirin on hemostasis is to impair platelet aggregation via …

BACKGROUND: The absolute risk of recurrences among patients using aspirin for
prevention of cardiovascular events remains high. Persistent platelet reactivity despite …

WHAT IS ALREADY KNOWN ABOUT THIS SUBJECT• A genetic basis for aspirin resistance
has been postulated to exist.• The individual studies published have been too small to allow …

The definition 'resistance to antiplatelet drugs' should be limited to situations in which failure
of the drug to hit its pharmacological target has been documented by specific laboratory …

Aspirin is one of the cornerstones of treatment for cardiovascular disease. However, some
patients may be 'resistant'to its effect: this is associated with adverse cardiovascular …