Mitochondria are the power stations of the eukaryotic cell, using the energy released by the
oxidation of glucose and other sugars to produce ATP. Electrons are transferred from NADH …

Cytochrome c oxidase (CcO) is the terminal oxidase of the mitochondrial electron transport
chain. This bigenomic enzyme in mammals contains 13 subunits of which the 3 catalytic …

Cytochrome c oxidase (COX) from mammals and birds is composed of 13 subunits. The
three catalytic subunits I-III are encoded by mitochondrial DNA, the ten nuclear-coded …

Mitochondria have emerged as critical platforms for antiviral innate immune signaling. This
is due in large part to the mitochondrial localization of the innate immune signaling adaptor …

Phenethyl isothiocyanate (PEITC), a constituent of edible cruciferous vegetables such as
watercress, not only affords significant protection against chemically induced cancer in …

The inducible form of Heme Oxygenase-1 (HO-1), a major endoplasmic reticulum (ER)
associated heme protein, is known to play important roles in protection against oxidative and …

Morphological and functional alterations of hepatic mitochondria have been documented in
patients with alcoholic liver disease (ALD). Our recent study demonstrated that zinc level …

Mitochondrial dysfunction is increasingly recognized as a major factor in the etiology and
progression of numerous human diseases, such as (neuro-) degeneration, ischemia …

Innate antiviral immunity is the first line of the host defense system that rapidly detects
invading viruses. Mitochondria function as platforms for innate antiviral signal transduction in …

Cytochrome c oxidase (COX) deficiencies are one of the most common defects of the
respiratory chain found in mitochondrial diseases. COX is a multimeric inner mitochondrial …