The foundation of laboratory hematologic diagnosis is the complete blood count and review
of the peripheral smear. In patients with anemia, the peripheral smear permits interpretation …

Objective To provide recommendations to physicians, midwives, genetic counsellors, and
clinical laboratory scientists involved in pre-conceptional or prenatal care regarding carrier …

The aim of carrier testing is to identify carrier couples at risk of having offspring with a
serious genetic (autosomal recessive) disorder. Carrier couples are offered genetic …

Hemoglobin disorders are among the most common genetic diseases worldwide. Molecular
diagnosis is helpful in cases where the diagnosis is uncertain and for genetic counseling …

Hematologic disorders are implicated in approximately 10% to 27% of cases of nonimmune
hydrops fetalis. In almost all of these disorders, anemia leading to heart failure, edema …

Although rats are preferred over mice as an animal model, transgenic animals are
generated predominantly using mouse embryos. There are limitations in the generation of …

OBJECTIVE: Increased zinc protoporphyrin/heme (ZPP/H) ratio has been used in pediatrics
to screen for iron deficiency and lead poisoning. This study was conducted to determine …

Our earlier studies suggested an association between α-thalassemia and hypertension. We
postulated that this association might involve trapping of the vasodilator nitric oxide (NO) by …

Abstract Hb Westmead (α122 (H5) His> Gln)(HBA2: c. 369C> G) is a common α-globin
variant causing α-thalassemia (α-thal) in Mainland China. In this study, we report the …

Couples in whom one is heterozygous for α‐thalassaemia‐1 and the other is heterozygous
for β‐thalassaemia are assumed not to be at risk of having offspring with homozygous α …