Host Innate Immune Responses to Acinetobacter baumannii Infection

W Chen - Frontiers in Cellular and Infection Microbiology, 2020 - frontiersin.org
Acinetobacter baumannii has emerged as a major threat to global public health and is one
of the key human pathogens in healthcare (nosocomial and community-acquired) …

Innate immune responses in pneumonia

FT Korkmaz, KE Traber - Pneumonia, 2023 - Springer
The lungs are an immunologically unique environment; they are exposed to innumerable
pathogens and particulate matter daily. Appropriate clearance of pathogens and response to …

[HTML][HTML] Bacterial hydrophilins promote pathogen desiccation tolerance

ER Green, JN Fakhoury, AJ Monteith, H Pi… - Cell host & …, 2022 - cell.com
Acinetobacter baumannii is a leading cause of hospital-acquired infections, where
outbreaks are driven by its ability to persist on surfaces in a desiccated state. Here, we show …

The tRNA methyltransferase TrmB is critical for Acinetobacter baumannii stress responses and pulmonary infection

JC McGuffey, CD Jackson-Litteken, G Di Venanzio… - Mbio, 2023 - Am Soc Microbiol
Successful pathogens must be able to adapt to a multitude of stressors imposed by their
host. Acinetobacter baumannii has emerged as a major global health threat due to its …

Transitional premonocytes emerge in the periphery for host defense against bacterial infections

YC Teh, MY Chooi, D Liu, I Kwok, GC Lai… - Science …, 2022 - science.org
Circulating Ly6Chi monocytes often undergo cellular death upon exhaustion of their
antibacterial effector functions, which limits their capacity for subsequent macrophage …

Virulence Factors and Pathogenicity Mechanisms of Acinetobacter baumannii in Respiratory Infectious Diseases

Y Yao, Q Chen, H Zhou - Antibiotics, 2023 - mdpi.com
Acinetobacter baumannii (A. baumannii) has become a notorious pathogen causing
nosocomial and community-acquired infections, especially ventilator-associated …

Replicative Acinetobacter baumannii strains interfere with phagosomal maturation by modulating the vacuolar pH

JS Distel, G Di Venanzio, JJ Mackel, DA Rosen… - PLoS …, 2023 - journals.plos.org
Bacterial pneumonia is a common infection of the lower respiratory tract that can afflict
patients of all ages. Multidrug-resistant strains of Acinetobacter baumannii are increasingly …

Overexpressing long non-coding RNA OIP5-AS1 ameliorates sepsis-induced lung injury in a rat model via regulating the miR-128-3p/Sirtuin-1 pathway

H Xie, H Chai, X Du, R Cui, Y Dong - Bioengineered, 2021 - Taylor & Francis
Sepsis, resulting from infections, is a systemic inflammatory response syndrome with a high
fatality rate. The present study revolves around probing into the function and molecular …

NAAA-regulated lipid signaling in monocytes controls the induction of hyperalgesic priming in mice

Y Fotio, A Mabou Tagne, E Squire, H Lee… - Nature …, 2024 - nature.com
Circulating monocytes participate in pain chronification but the molecular events that cause
their deployment are unclear. Using a mouse model of hyperalgesic priming (HP), we show …

Neutrophil and macrophage response in Acinetobacter Baumannii Infection and their relationship to Lung Injury

Z Liu, W Xu - Frontiers in Cellular and Infection Microbiology, 2022 - frontiersin.org
Acinetobacter baumannii (AB) infection has become a threat to global public health. AB is
one of the main pathogens causing nosocomial infections, especially ventilator-associated …