Hyperpolarized 129Xe MRI of the human lung

JP Mugler III, TA Altes - Journal of Magnetic Resonance …, 2013 - Wiley Online Library
By permitting direct visualization of the airspaces of the lung, magnetic resonance imaging
(MRI) using hyperpolarized gases provides unique strategies for evaluating pulmonary …

Imaging of lung function using hyperpolarized helium‐3 magnetic resonance imaging: review of current and emerging translational methods and applications

S Fain, ML Schiebler, DG McCormack… - Journal of magnetic …, 2010 - Wiley Online Library
During the past several years there has been extensive development and application of
hyperpolarized helium‐3 (HP 3He) magnetic resonance imaging (MRI) in clinical respiratory …

Functional imaging of the lungs with gas agents

SJ Kruger, SK Nagle, MJ Couch, Y Ohno… - Journal of Magnetic …, 2016 - Wiley Online Library
This review focuses on the state‐of‐the‐art of the three major classes of gas contrast agents
used in magnetic resonance imaging (MRI)—hyperpolarized (HP) gas, molecular oxygen …

Functional lung imaging using hyperpolarized gas MRI

SB Fain, FR Korosec, JH Holmes… - Journal of Magnetic …, 2007 - Wiley Online Library
The noninvasive assessment of lung function using imaging is increasingly of interest for the
study of lung diseases, including chronic obstructive pulmonary disease (COPD) and …

State of the Art. A structural and functional assessment of the lung via multidetector-row computed tomography: phenotyping chronic obstructive pulmonary disease

EA Hoffman, BA Simon, G McLennan - Proceedings of the American …, 2006 - atsjournals.org
With advances in multidetector-row computed tomography (MDCT), it is now possible to
image the lung in 10 s or less and accurately extract the lungs, lobes, and airway tree to the …

Quantitative imaging metrics for the assessment of pulmonary pathophysiology: an official American Thoracic Society and Fleischner Society joint workshop report

CCW Hsia, JHT Bates, B Driehuys, SB Fain… - Annals of the …, 2023 - atsjournals.org
Multiple thoracic imaging modalities have been developed to link structure to function in the
diagnosis and monitoring of lung disease. Volumetric computed tomography (CT) renders …

Translational applications of hyperpolarized 3He and 129Xe

LL Walkup, JC Woods - NMR in Biomedicine, 2014 - Wiley Online Library
Clinical magnetic resonance imaging of the lung is technologically challenging, yet over the
past two decades hyperpolarized noble gas (3He and 129Xe) imaging has demonstrated …

Hyperpolarized gas MRI in pulmonology

AL Kern, J Vogel-Claussen - The British journal of radiology, 2018 - academic.oup.com
Lung diseases have a high prevalence amongst the world population and their early
diagnosis has been pointed out to be key for successful treatment. However, there is still a …

An open-access, very-low-field MRI system for posture-dependent 3He human lung imaging

LL Tsai, RW Mair, MS Rosen, S Patz… - Journal of Magnetic …, 2008 - Elsevier
We describe the design and operation of an open-access, very-low-field, magnetic
resonance imaging (MRI) system for in vivo hyperpolarized 3He imaging of the human …

Magnetic resonance imaging with hyperpolarized agents: methods and applications

EB Adamson, KD Ludwig, DG Mummy… - Physics in Medicine & …, 2017 - iopscience.iop.org
In the past decade, hyperpolarized (HP) contrast agents have been under active
development for MRI applications to address the twin challenges of functional and …