PIWI-interacting RNAs: small RNAs with big functions
In animals, PIWI-interacting RNAs (piRNAs) of 21–35 nucleotides in length silence
transposable elements, regulate gene expression and fight viral infection. piRNAs guide …
transposable elements, regulate gene expression and fight viral infection. piRNAs guide …
piRNAs: from biogenesis to function
EM Weick, EA Miska - Development, 2014 - journals.biologists.com
Distinguishing self from non-self plays a crucial role in safeguarding the germlines of
metazoa from mobile DNA elements. Since their discovery less than a decade ago, Piwi …
metazoa from mobile DNA elements. Since their discovery less than a decade ago, Piwi …
[HTML][HTML] Starvation-induced transgenerational inheritance of small RNAs in C. elegans
Evidence from animal studies and human famines suggests that starvation may affect the
health of the progeny of famished individuals. However, it is not clear whether starvation …
health of the progeny of famished individuals. However, it is not clear whether starvation …
MODOMICS: a database of RNA modification pathways—2013 update
MA Machnicka, K Milanowska… - Nucleic acids …, 2012 - academic.oup.com
MODOMICS is a database of RNA modifications that provides comprehensive information
concerning the chemical structures of modified ribonucleosides, their biosynthetic pathways …
concerning the chemical structures of modified ribonucleosides, their biosynthetic pathways …
Nucleic acid modifications in regulation of gene expression
Nucleic acids carry a wide range of different chemical modifications. In contrast to previous
views that these modifications are static and only play fine-tuning functions, recent research …
views that these modifications are static and only play fine-tuning functions, recent research …
A single mechanism of biogenesis, initiated and directed by PIWI proteins, explains piRNA production in most animals
In animals, PIWI-interacting RNAs (piRNAs) guide PIWI proteins to silence transposons and
regulate gene expression. The mechanisms for making piRNAs have been proposed to …
regulate gene expression. The mechanisms for making piRNAs have been proposed to …
Identification and functional analysis of the pre-piRNA 3′ trimmer in silkworms
PIWI-interacting RNAs (piRNAs) play a crucial role in transposon silencing in animal germ
cells. In piRNA biogenesis, single-stranded piRNA intermediates are loaded into PIWI-clade …
cells. In piRNA biogenesis, single-stranded piRNA intermediates are loaded into PIWI-clade …
The biogenesis and functions of piRNAs in human diseases
X Wu, Y Pan, Y Fang, J Zhang, M Xie, F Yang… - … Therapy-Nucleic Acids, 2020 - cell.com
Piwi-interacting RNAs (piRNAs) are a novel type of small noncoding RNAs, which are 26–30
nt in length and bind to Piwi proteins. These short RNAs were originally discovered in …
nt in length and bind to Piwi proteins. These short RNAs were originally discovered in …
The RNase PARN-1 trims piRNA 3′ ends to promote transcriptome surveillance in C. elegans
Piwi-interacting RNAs (piRNAs) engage Piwi proteins to suppress transposons and are
essential for fertility in diverse organisms. An interesting feature of piRNAs is that, while …
essential for fertility in diverse organisms. An interesting feature of piRNAs is that, while …
Germ granules and gene regulation in the Caenorhabditis elegans germline
CM Phillips, DL Updike - Genetics, 2022 - academic.oup.com
The transparency of Caenorhabditis elegans provides a unique window to observe and
study the function of germ granules. Germ granules are specialized ribonucleoprotein (RNP) …
study the function of germ granules. Germ granules are specialized ribonucleoprotein (RNP) …