Muscular dystrophies and congenital myopathies arise from specific genetic mutations
causing skeletal muscle weakness that reduces quality of life. Muscle health relies on …

Clubfoot or talipes equinovarus (TEV) is an inborn three-dimensional deformity of leg, ankle
and foot. It results from structural defects of several tissues of foot and lower leg leading to …

Designing an RNA-interacting molecule that displays high therapeutic efficacy while
retaining specificity within a broad concentration range remains a challenging task …

The phosphoinositide phosphatase synaptojanin 1 (SYNJ1) is a key regulator of synaptic
function. We first tested whether SYNJ1 contributes to phenotypic variations in familial …

Across human protein-coding genes, the human neuron-specific genes, RIT2 and GPM6B,
contain the two longest GA short tandem repeats (STRs) of 11 and 9-repeats, respectively …

Horns are paired appendages on the head of bovine species, comprising an inner bony
core and outer keratin sheath. The horn bud forms during early fetal development but …

Purpose Skeletal muscle growth and regeneration rely on muscle stem cells, called satellite
cells. Specific transcription factors, particularly PAX7, are key regulators of the function of …

Adult mouse muscle satellite cells (MuSCs) are quiescent in uninjured muscles. Upon
muscle injury, MuSCs exit quiescence, reenter the cell cycle to proliferate and self-renew …

Background: Retinitis pigmentosa (RP) is a heterogeneous group of ocular dystrophy. It is
challenging to identify the underlying genetic defect in individuals with RP due to huge …

The lifespan of double-positive (DP) thymocytes is critical for intrathymic development and
shaping the peripheral T cell repertoire. However, the molecular mechanisms that control …