Multiple lines of evidence implicate dysregulated microglia-mediated synaptic pruning in the
pathophysiology of schizophrenia. In vitro human cellular studies represent a promising …

In multiple sclerosis (MS) and other neurological diseases, the failure to repair demyelinated
lesions contributes to axonal damage and clinical disability. Here, we provide evidence that …

Synaptic dysfunction is thought to play important roles in the pathophysiology of many
neurological diseases, including Alzheimer's disease, Parkinson's disease, and …

Synaptosomes are frequently used research objects in neurobiology studies focusing on
synaptic transmission as they mimic several aspects of the physiological synaptic functions …

Neural cell adhesion molecules 1 (NCAM1) and 2 (NCAM2) belong to the cell adhesion
molecules of the immunoglobulin superfamily and have been shown to regulate formation …

Neurotoxicity induced by exposure to heavy metal lead (Pb) is a concern of utmost
importance particularly for countries with industrial-based economies. The developing brain …

Mitochondrial function at synapses can be assessed in isolated nerve terminals.
Synaptosomes are structures obtained in vitro by detaching the nerve endings from …

Microglia, the resident brain immune cells, play a critical role in normal brain development,
and are impacted by the intrauterine environment, including maternal immune activation and …

The involvement of mitochondrial dysfunction in cystatin B (CSTB) deficiency has been
suggested, but its role in the onset of neurodegeneration, myoclonus, and ataxia in the …

Proper transport of RNAs to synapses is essential for localized translation of proteins in
response to synaptic signals and synaptic plasticity. Alzheimer's disease (AD) is a …