Abstract Tofilon, PJ and Fike, JR The Radioresponse of the Central Nervous System: A
Dynamic Process. Radiation continues to be a major treatment modality for tumors located …

Proprotein convertases (PCs) are a group of Ca2+‐dependent serine proteases that have
homology to the endoproteases subtilisin (bacteria) and kexin (yeast). This group is …

Despite an estimated heritability of~ 50%, genome-wide association studies of opioid use
disorder (OUD) have revealed few genome-wide significant loci. We conducted a cross …

Proteolytic processing of the transforming growth factor β precursor (pro-TGFβ) is an
essential step in the formation of the biologically active TGFβ homodimeric protein (TGFβ) …

The prohormone convertase SPC2 (PC2) participates in the processing of proinsulin,
proglucagon, and a variety of other neuroendocrine precursors, acting either alone or in …

Before intoxication can occur, anthrax toxin protective antigen (PA), Pseudomonas exotoxin
A (PE), and diphtheria toxin (DT) must be activated by proteolytic cleavage at specific amino …

Bone morphogenetic protein-4 (BMP-4) is a multifunctional developmental regulator. BMP-4
is synthesized as an inactive precursor that is proteolytically activated by cleavage following …

The transparency of the cornea along with its dense sensory innervation and resident
leukocyte populations make it an ideal tissue to study interactions between the nervous and …

A. Biosynthesis and processing of pro-TRH B. Intracellular sites of pro-TRH processing C.
Tissue-specific processing of pro-TRH D. The role of PCs and CPs E. Neuropeptide and …

Proprotein convertase subtilisin/kexin type 9 (PCSK9) has a crucial role in lipid metabolism,
particularly due to its function in low‐density lipoprotein receptor degradation. Gain‐of …