The eukaryotic cell is compartmentalized into subcellular niches, including membrane-
bound and membrane-less organelles. Proteins localize to these niches to fulfil their …

Ribosomes interact with a variety of different protein biogenesis factors that guide newly
synthesized proteins to their native 3D shapes and cellular localization. Depending on the …

The dynamic ribosome–translocon complex, which resides at the endoplasmic reticulum
(ER) membrane, produces a major fraction of the human proteome,. It governs the synthesis …

The endoplasmic reticulum (ER) translocon complex is the main gate into the secretory
pathway, facilitating the translocation of nascent peptides into the ER lumen or their …

During cotranslational translocation, the signal peptide of a nascent chain binds Sec61
translocon to initiate protein transport through the endoplasmic reticulum (ER) membrane …

The translocon-associated protein (TRAP) complex resides in the endoplasmic reticulum
(ER) membrane and interacts with the Sec translocon and the ribosome to facilitate …

The eukaryotic endoplasmic reticulum (ER) membrane contains essential complexes that
oversee protein biogenesis and lipid metabolism, impacting nearly all aspects of cell …

Viruses are obligate intracellular pathogens that utilize cellular machinery for many aspects
of their propagation and effective egress of virus particles from host cells is one important …

Cleavable endoplasmic reticulum (ER) signal peptides (SPs) and other non-cleavable
signal sequences target roughly a quarter of the human proteome to the ER. These short …

The rough endoplasmic reticulum (ER) of nucleated human cells has crucial functions in
protein biogenesis, calcium (Ca2+) homeostasis, and signal transduction. Among the …