Microtubule-binding agents: a dynamic field of cancer therapeutics
C Dumontet, MA Jordan - Nature reviews Drug discovery, 2010 - nature.com
Microtubules are dynamic filamentous cytoskeletal proteins composed of tubulin and are an
important therapeutic target in tumour cells. Agents that bind to microtubules have been part …
important therapeutic target in tumour cells. Agents that bind to microtubules have been part …
Destruction of tumor vasculature by vascular disrupting agents in overcoming the limitation of EPR effect
Nanomedicine greatly improves the efficiency in the delivery of antitumor drugs into the
tumor, but insufficient tumoral penetration impairs the therapeutic efficacy of most …
tumor, but insufficient tumoral penetration impairs the therapeutic efficacy of most …
[图书][B] Anticancer agents from natural products
GM Cragg, DGI Kingston, DJ Newman - 2005 - taylorfrancis.com
Plants, marine organisms, and microorganisms have evolved complex chemical defense
and signaling systems that are designed to protect them from predators and provide other …
and signaling systems that are designed to protect them from predators and provide other …
Electrophilic natural products and their biological targets
Covering: 1900 to 2011 The study of biologically active natural products has resulted in
seminal contributions to our understanding of living systems. In the case of electrophilic …
seminal contributions to our understanding of living systems. In the case of electrophilic …
The performance of several docking programs at reproducing protein–macrolide-like crystal structures
A Castro-Alvarez, AM Costa, J Vilarrasa - Molecules, 2017 - mdpi.com
The accuracy of five docking programs at reproducing crystallographic structures of
complexes of 8 macrolides and 12 related macrocyclic structures, all with their …
complexes of 8 macrolides and 12 related macrocyclic structures, all with their …
Microtubule stabilizing agents as potential treatment for Alzheimer's disease and related neurodegenerative tauopathies
C Ballatore, KR Brunden, DM Huryn, JQ Trojanowski… - 2012 - ACS Publications
The microtubule (MT) associated protein tau, which is highly expressed in the axons of
neurons, is an endogenous MT-stabilizing agent that plays an important role in axonal …
neurons, is an endogenous MT-stabilizing agent that plays an important role in axonal …
Overcoming tumor multidrug resistance using drugs able to evade P‐glycoprotein or to exploit its expression
S Nobili, I Landini, T Mazzei… - Medicinal research reviews, 2012 - Wiley Online Library
Multidrug resistance (MDR) is a major obstacle to the effective treatment of cancer. Cellular
overproduction of P‐glycoprotein (P‐gp), which acts as an efflux pump for various anticancer …
overproduction of P‐glycoprotein (P‐gp), which acts as an efflux pump for various anticancer …
Natural products and their biological targets: proteomic and metabolomic labeling strategies
T Böttcher, M Pitscheider… - Angewandte Chemie …, 2010 - Wiley Online Library
Activity‐based protein profiling (ABPP) has matured into a standard method for the fast,
sensitive, and selective identification of enzyme activity and inhibitors in proteomes. By …
sensitive, and selective identification of enzyme activity and inhibitors in proteomes. By …
Recent progress with microtubule stabilizers: new compounds, binding modes and cellular activities
CC Rohena, SL Mooberry - Natural product reports, 2014 - pubs.rsc.org
Covering: late 2008 to August 2013 Nature has yielded numerous classes of chemically
distinct microtubule stabilizers. Several of these, including paclitaxel (Taxol) and docetaxel …
distinct microtubule stabilizers. Several of these, including paclitaxel (Taxol) and docetaxel …
Microtubule active agents: beyond the taxane frontier
PG Morris, MN Fornier - Clinical cancer research, 2008 - AACR
Microtubules are essential to cell transport, signaling, and mitosis. An increasing range of
anticancer drugs interferes with the normal formation and function of microtubules. Vinca …
anticancer drugs interferes with the normal formation and function of microtubules. Vinca …